Tumor microenvironment interactions

Ben-Baruch, A. (2003). Host microenvironment in breast cancer development Inflammatory cells, cytokines and chemokines in breast cancer progression Reciprocal tumor-microenvironment interactions. Breast Cancer Res. 5, 31-36. 

Cell-Cell Interaction in Tumor Microenvironment Limitations... 

Our third microfluidic device described in this chapter is a miniature tumor microenvironment system in which a cluster of tumor cells (i.e., a spheroid), fibroblasts, and endothelial cells are cocultured in a system that mimics the tumor microenvironment (Fig. 6) (Hockemeyer et al., 2014). This device provides an ideal tool to study these cell—ceU interactions in a simulated tumor microenvironment. 

In this chapter, the consequences of the irregular structure and function of the tumor microcirculation and the self-perpetuating hostile pathophysiological microenvironment (via a vicious circle) will be described. This overview considers, inter alia, many metabolic, biophysical, and physico-biochemical parameters of the tumor microenvironment rather than focusing on the complex composition of the tumor stroma, the cells therein, and their factors secreted, the key components of the tumor stroma, and the interactions between tumor cells, the extracellular matrix, and stromal cells (for reviews see, e.g., Mueller and Fusenig 2004 Witz and Levy-Nissenbaum 2006 Weinberg 2008 Ariztia etal. 2006 Cunha etal. 2003 Park etal. 2000 Liotta and Kohn 2001 Fidler 2002 Unger and Weaver 2003 Denko et al. 2003). 

Ramanathan-Girish S, Boroujerdi M (2001) Contradistinction between doxorubicin and epirubicin In vitro interaction with blood components. J Pharm Pharmacol 53 815-821 Reynolds TY, Rockwell S, Glazer PM (1996) Genetic instability induced by the tumor microenvironment. Cancer Res 56 5754-5757... 

Nitric oxide (NO) is a key molecule in the regulation of rnmor-microenvironment interactions. One of the NO functions is the regulation of tumor cell cross talk with stromal cells. Because tumor cell anoikis and invasion are both regulated by... 

Rotating culture vessels such as simulated microgravity systems are primarily used to study 3-D tumor growth and differentiation. However, mixed cell populations combined with matrix proteins can be used to generate a complex microenvironment in which cell-cell interactions and invasion can be measured (95). A similar system has also been described for the coculture of endothelial cells, myofibroblasts, and tumor cell clusters embedded in Matrigel . Differential labeling of the cell populations enables their invasion and the effects of inhibitors to be measured (96). 

Bourguignon, L.Y.etal., CD44 interaction with Na+-H+exchanger (NHE1) creates acidic microenvironments leading to hyaluronidase-2 and cathepsin B activation and breast tumor cell invasion, J. Biol. 

---