Big Chemical Encyclopedia

Chemical substances, components, reactions, process design ...

Articles Figures Tables About

Tumor markers tissue production

With few exceptions, an increase in the activity or mass of an enzyme or isoenzyme is not specific or sensitive enough to be used for identifying the type of cancer or the specific organ involvement. An exception is PSA. PSA has mild protease activity and amino acid sequence homology with serine protease of the kallikrein family.It is expressed by normal, benign, hyperplastic, and cancerous prostate glands and minimally by other tissue. Until the application of PSA as a marker for prostate cancer, tumor enzymes had lost most of their popularity for use as cancer markers. Enzymes were used historically as tumor markers before the discovery of oncofetal antigens and the advent of monoclonal antibodies. The abnormalities of enzymes as a marker for cancer are either the expression of the fetal form of the enzyme (isozyme) or the ectopic production of enzymes. [Pg.754]

Although pancreatitis, severe injury, and inflammation can all increase its levels, TATI can stfll function as a relatively good tumor marker for various cancers. In most cancers, the increase in TATI is due to tumor production however, inflammation associated with tissue destruction contributes to the overall TATI increase. Serum and urine concentrations correlate well, but because of greater variation in urine, serum is preferred. [Pg.764]

We do not yet fully understand why elevated levels of urinary polyamines occur in patients with cancer, and why DiAcSpm behaves differently than other polyamine species, making it a useful tumor marker. It is unclear where DiAcSpm is produced and how it is excreted in the urine. Increased production of DiAcSpm in cancer patients may occur in two ways (1) cancer cells may generate DiAcSpm from intracellular polyamines that are produced at increased levels by actively growing cells, or (2) healthy cells or tissues may in fact be producing increased amounts of DiAcSpm using the increased levels of polyamines in the bloodstream of cancer patients as substrates. [Pg.309]

FIGURE 2.15 Detection of microsatellite instability using the NCI recommended panel of five microsatellite markers. In this colon cancer sample, all five markers show microsatellite instability, which manifests as change in size of microsatellite repeats seen on capillary gel electropherograms of tumor PCR products. Electropherograms of normal tissue PCR products are used as a negative control. [Pg.54]

Lin F, Shi J, Liu Li, et al. Immunohistochemical detection of the von Hippel-Lindau gene product (pVLiL) in human tissues and tumors A useful marker for metastatic renal cell carcinoma and clear cell carcinoma of the ovary and uterus. Am J Clin Pathol. 2008 129 592-605. [Pg.889]


See other pages where Tumor markers tissue production is mentioned: [Pg.170]    [Pg.746]    [Pg.765]    [Pg.781]    [Pg.201]    [Pg.203]    [Pg.311]    [Pg.329]    [Pg.420]    [Pg.407]    [Pg.214]    [Pg.313]    [Pg.116]    [Pg.121]    [Pg.190]    [Pg.2131]    [Pg.53]    [Pg.163]    [Pg.181]    [Pg.238]    [Pg.292]    [Pg.71]    [Pg.143]    [Pg.218]    [Pg.400]    [Pg.2152]    [Pg.152]    [Pg.625]    [Pg.501]    [Pg.11]    [Pg.226]    [Pg.303]   
See also in sourсe #XX -- [ Pg.746 ]




SEARCH



Markers tissue production

Tissue Markers

Tissue products

Tumor markers

Tumor production

© 2024 chempedia.info