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Tubulin-tyrosine ligase

Initial rate patterns for bovine brain tubulin tyrosine ligase (Reaction detyrosinated tubulin (Tb) + i-tyrosine + ATP = tyrosinated tubulin + ADP + orthophosphate). The results of each set of experiments are shown as a single frame containing the same data points plotted as a function of one or the other varied substrate. The nonvar-ied substrate concentration is shown in the lower right-hand corner of every double-reciprocal plot. (From ref. 2.)... [Pg.298]

A three-substrate, three-product enzyme-catalyzed reaction scheme in which the three substrates (A, B, and C) and three products (P, Q, and R) can bind to and be released in any order. A number of enzymes have been reported to have this mechanism for example, adenylosuccinate synthetase , glutamate dehydrogenase, glutamine synthetase , formyltetrahydrofolate synthetase, and tubulin tyrosine ligase . See Multisubstrate Mechanisms... [Pg.604]

RNA POLYMERASES SELENOPHOSPHATE SYNTHETASE SHIKIMATE KINASE SULFATE ADENYLYLTRANSFERASE TUBULIN TYROSINE LIGASE UBIQUITIN-PROTEIN LIGASES d-XYLULOKINASE ATP-dependent protease La,... [Pg.725]

SELENOPHOSPHATE SYNTHETASE STARCH PHOSPHORYLASE SUCCINYL-CoA SYNTHETASE SUCROSE PHOSPHORYLASE TUBULIN.TYROSINE LIGASE ORTHOPHOSPHATE CONTINUOUS ASSAY Orthovanadate,... [Pg.768]

MICROTUBULE ASSEMBLY KINETICS TUBULIN TYROSINE LIGASE ARSENOLYSIS Tungsten,... [Pg.786]

A tyrosine ligase present in brain extracts has been shown to add a tyrosine residue specifically to the carboxyl terminal end of a-tubulin (236,249). The function of this enzyme in the assembly of the tubulin system is not clear since both tyrosylated and untyrosylated a-tubulin dimers can polymerize. [Pg.147]

Dibutyryl cAMP applied to Chinese hamster ovary cells in culture causes an increase in the number of microtubules per unit volume of cytoplasm (Porter et al., 1974). Microtubules end on microtubule organizing centers. A microtubule-associated protein, tau, will facilitate the initiation of tubulin polymerization and its subsequent elongation (Witman et al., 1976). The a chain of tubulin can be acted on by the enzyme tyrosyltubulin ligase, so as to add tyrosine, phenylalanine, or 3,4-dihydroxyphenylalanine to the C-terminus (Deanin and Gordon, 1976). [Pg.281]


See other pages where Tubulin-tyrosine ligase is mentioned: [Pg.127]    [Pg.153]    [Pg.157]    [Pg.689]    [Pg.71]    [Pg.73]    [Pg.117]    [Pg.117]    [Pg.127]    [Pg.153]    [Pg.157]    [Pg.689]    [Pg.71]    [Pg.73]    [Pg.117]    [Pg.117]    [Pg.267]    [Pg.482]   
See also in sourсe #XX -- [ Pg.73 ]




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