Trypanosoma cruzi control

Chagas disease, both the serum immunoglobulin levels and complement titers were similar to those of other uninfected subjects living in the same area. The experimental findings in C.,H mice, that thymus-dependent cell mediated immune mechanisms arc involved in controlling infection with Trypanosoma cruzi appear promising. 

Oliveira, M. M., Antunes, A. and de Mello, F. G. (1984) Growth of Trypanosoma cruzi epimastigotes controlled by shifts in cyclic AMP mediated by adrenergic ligands. Mol. Biochem. Parasitol. 11 283-292. 

Preliminary evidence suggest that piquerol A (26a) can be a potential resource in the control of Chagas disease (American trypanosomiasis), an endemic illness which afflicts millions of people in Latin America [116]. The causal agent is the protozoan Trypanosoma cruzi, which is transmitted by insect vectors. 

Williams GT (in press) Control of differentiation in Trypanosoma cruzi. Curr Top Microbiol Immunol... 

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