Troger skeletons

CSPs (CTA-I and CTA-II) have inverse selectivity for Troger s base and trans-1,2-diphenyloxirane racemates. These characteristics of CTA CSPs are responsible for good chiral resolution of small cychc carbonyl compounds [42]. In 2001 Aboul-Enein and Ah [63] observed the reversed order of elution of nebivolol on a Chiralpak AD column when ethanol and 2-propanol were used separately as the mobile phases. Table 1 presents selectivity data for the polysaccharide-based CSPs. Okamoto et al. [42] observed that the introduction of a methyl group at the para position of cellulose tribenzoate results in a dramatic shift of the structural selectivity toward aromatic compounds with larger skeletons, and its selectivity was rather similar to that of cellulose tricinnamate. 

Instead, a tweezer shape was shown by the bis-Troger base skeleton of 18 with the aromatic arms lying almost parallel with each other (23.1°), with a distance between its centroids of 4.368(5) A. The central phenyl ring is almost orthogonal to the external aromatic arms (a, 79.3° b, 88.6°). The molecular packing showed that in the c-direction every two molecules are intercalated each other in such a way that, in the case of 18a, the nitro arm of one molecule is... 

Pardo, C. Sesmilo, E. Gutierrez-Puebla. E. Monge, A. Elguero, J. Frucliier. A. New chiral molecular tweezers with a bis-Troger s base skeleton. J. Org. Chem. 2001, 66. 1607-1611. 

Yashima. E. Akashi, M. Miyauchi, N. Chiral bis(l,10-phenanthroline) with Troger s base skeleton. Synthesis and interaction with DNA. Chem. Eett. 1991. 1017-1020. 

SYNTHESIS OF MACROCYCLES HAVING TROGER BASE SKELETONS "[2.2]CYCLIC TROGER BASE" ... 

With the hope of obtaining such macrocycles, we tried to synthesize macrocyclic compounds having Troger base skeletons as chiral host molecules. ... 

Wieland This was the first classical demonstration that optical activity was due to an asymmetric trivalent nitrogen atom. Cyclophanes 2 in Fig. 1 consisting of two Troger base skeletons... 

SYNTHESIS OF MACROCYCLES HAVING TROGER BASE SKELETONS... 

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