Tweezers, molecular chiral

A new chiral benzothiazine ligand 205 was synthesized by Harmata and co-workers <06JOC3650>. It could be converted into a chiral molecular receptor 207 in a simple way. This chiral species 207 could be used as a new class of chiral molecular tweezers. The synthesis of 205 commenced with the protection of the commercially available compound 202, which was then coupled with f7tj-sulfoximinc 77b using the one-pot, one-operation procedure <99AG(E)2419> affording enantiomerically pure benzothiazine 204. This was followed by deprotection to produce benzothiazine 205 in good yield. 

Among the first molecular tweezers, which were also chiral, were those prepared by the Karmata group. This... 

Fig. 5 Three different classes of chiral molecular tweezers prepared by Harmata and coworkers. (From Refs. [20-23].)...

Design and application of molecular tweezers, particularly those that are chiral and those that can bind multiple n systems within their clefts, are only beginning to be explored. Molecular tweezers and other molecular clefts have the potential to dimerize to produce molecular... 

Pardo, C. Sesmilo, E. Gutierrez-Puebla. E. Monge, A. Elguero, J. Frucliier. A. New chiral molecular tweezers with a bis-Troger s base skeleton. J. Org. Chem. 2001, 66. 1607-1611. 

Figure 6.29 (a) molecular model of the chiral tweezers 6.53, (b) the chiral guest that forms part of... 

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