Tritium strategies

STRATEGY The number of tritium nuclei in the sample is proportional to the total mass m of tritium, so Eq. 3 can be expressed as... 

The organization of this book is as follows. The remainder of this chapter provides short accounts of purification, analysis and storage and stability of compounds labeled with carbon-14 and tritium, and descriptions of some common techniques and technologies unique to work with these isotopes. Chapter 2 discusses some strategies particularly appropriate for planning syntheses of compounds labeled with carbon-14 and tritium, an appropriate topic for inclusion because there are distinct differences vis-a-vis the ways nonisotopic synthetic problems are approached, and an appreciation of these differences is... 

In practice, more than one approach might be applicable to the labeling of a given target. In order to identify the most effective strategy, a number of issues, peculiar to the preparation of compounds labeled with tritium or carbon-14, warrant consideration. 

Figure 2.14 Use of a multistep disconnection/reconnection strategy for preparing tritium-labeled paclitaxel...

A common strategy for tritium labeling is the oxidation-reduction approach, which provides fast and direct access to structurally complex molecules. While in the vast majority of cases the introduction of the label can be accomplished by reduction using one of many available selective reagents, regioselective oxidation often remains a problem. 

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