Trisacryl microsphere

Other newer agents have been introduced for use in UFE. Gelatin-coated trisacryl microspheres (Embospheres, Biosphere Medical Inc., Rockland, MA) were the first spherical agents and offered the theoretical advantage of a more uniform and targeted embolization of the perifibroid plexus [15]. Their compressibility also made microcatheter clog-... 

Trisacryl gelatin microspheres (Embosphere) calibrated, flexible, non-aggregating... 

Chua GC, Wilsher M, Young MP, Manyonda I, Morgan R, Belli AM (2005) Comparison of particle penetration with non-spherical polyvinyl alcohol versus trisacryl gelatin microspheres in women undergoing premyomectomy uterine artery embolization. Clin Radiol 60 116-122... 

Fig. 2.5a,b. Trisacryl gelatin microspheres or embospheres (courtesy of Biosphere Medical), a Trisacryl gelatin microspheres in suspension, b Microscopic images demonstrating the spheres... 

The initial clinical experience with trisacryl gelatin microspheres was reported by Beaujeux et al. in 105 patients with tumors or arteriovenous malformations in the head, neck or spine [46]. From this experience, it was learned that the precise calibration of these spheres enables interventionalists to have good control over the desired site of occlusion by appropriate size selection. In addition, the embolization were clinically effective, demonstrating that complete devascularization of the target pathology was often not possible but may not have been necessary to meet the goals of the embolization procedure [46]. 

There have been complications reported in association with the use of trisacryl gelatin microspheres. De Blok et al. reported a case of fatal sepsis after uterine artery embolization performed with this agent. In this case, diffuse necrosis of the vaginal wall and cervix was found, attributed to distal penetration of spheres measuring 500-700 p in diameter... 

Laurent A, Beaujeux R, Wassef, M, et al. (1996) Trisacryl gelatin microspheres for therapeutic embolization, I development and in-vitro evaluation. Am J Neuroradiol 17 533-540... 

Bendszus M, Klein R, Burger R, et al. (2000) Efficacy of trisacryl gelatin microspheres versus polyvinyl alcohol particles in the preoperative embolization of meningiomas. AJNR Am J Neuroradiol 21 255-261... 

Spies JB, Benenati JF, Worthington-Kirsch RL,et al. (2001) Initial experience with the use of trisacryl gelatin microspheres for uterine artery embolization for leiomyomata. J Vase Interv Radiol 12 1059-1063... 

Fig. 10.6.5. In vivo detectability of 700-900 pm MR marked microspheres after renal artery embolization in the sheep. The left kidney has been emboli-zed with trisacryl-gelatin microspheres containing an MR marker (L), and the right kidney with control trisacryl-gelatin microspheres (R). MRI study of the explanted kidneys was performed 24 h after embolization (3D SPGR Tl, slice thickness). MR marked microspheres are detectable in the cortical area. No control microsphere is detected in the opposite side...

Verret, V., Wassef, M., Pelage, J.P., Ghegediban, S.H., Jouneau, L., Moine, L., et al., 2011. Influence of degradation on inflammatory profile of polyphosphazene coated PMMA and trisacryl gelatin microspheres in a sheep uterine artery embolization model. Biomaterials 32 (2), 339—351. 

Poly[bis-trifluoroethoxyphosphazene] (PTFEP) is another polymer that has utility in biomedical applications although since it is hydrophobic, its biodegradability is relatively limited and plays the role of a coating. Currently, microspheres consisting of a hydrophilic trisacryl gelatin encapsulated with PTFEP (150 pm thickness) are commercially available and have... 

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