2.4.6-tris- -1,3,5-triazine

Similarly, tristriazine derivatives are obtained from trichloro-tris-triazine. 

Tris(4-tert-butyl-3-hydroxy-2,6-dimethylben2yl)s-triazine-2,4,6-(lH,3H,5IT)trione [40601-76-1]... 

Strong bases, such as potassium acetate, potassium 2-ethylhexoate, or amine—epoxide combinations are the most useful trimerization catalysts. Also, some special tertiary amines, such as 2,4,6-tns(A7,A7-dimethylarninomethyl)phenol (DMT-30) (6), l,3,5-tris(3-dimethylaminopropyl)hexahydro-j -triazine (7), and ammonium salts (Dabco TMR) (8) are good trimerization catalysts. 

Perhaps the most firmly based report for the formation of an azete involves flash pyrolysis of tris(dimethylamino)triazine (303). This gave a red pyrolysate believed to contain the highly stabilized azete (304) on the basis of spectroscopic data. The putative azete decomposed only slowly at room temperature, but all attempts to trap it failed (73AG(E)847). Flash pyrolysis of other 1,2,3-triazines gives only acetylenes and nitriles and it is not possible to tell whether these are formed by direct <,2-l-<,2-l-<,2 fragmentation of the triazine or by prior extrusion of nitrogen and collapse to an azete (81JCR(S)162). 

Tris- (2-hydroxyphenyl)-triazine /OH OH Triazine Powerful but some absorption in visible range... 

Dichloro-s-triazine and its 6-alkyl analogs are as easily hydrolyzed by water as trichloro-s-triazine and, on suspension in aqueous ammonia (25°, 16 hr), the first is diaminated in good yield. 2,4-Bistrichloromethyl-6-methyl- and -6-phenyl-s-triazines (321) require a special procedure for mono-alkoxylation (0-20°, 16 hr, alcoholic triethylamine) disubstitution occurs at reflux temperature (8 hr). Aqueous triethylamine (100°, 3 hr) causes complete hydroxy-lation of 2,4,6-tris-trichloromethyl-s-triazine which can be mono-substituted with ammonia, methylamine, or phenoxide ion at 20°. 

Trichloro-s-triazine also reacts readily with carbon or phosphorus nucleophiles. Diethylmalonate anion forms a mono-derivative under mild conditions and the tri-substitution product (327) under vigorous conditions with excess nucleophile. Nucleophilic attack by the 7r-electrons of ketene diethylacetal to give 254 and of dimethylaniline to give 253 has been mentioned earlier. Two... 

Tris-methylthio-s-triazine undergoes similar displacement with methanolic methoxide. Its methylthio groups are substituted with sodium sulfide and with ammonia. Methylthio and carboxymethylthio substituents are readily hydrolyzed by dilute acid. ... 

Therapeutic Function Antineoplastic Chemical Name 2,4,6-Tris(1-aziridinyl)-s-triazine Common Name Tretamine Structural Formula ... 

Reaction of hydrazine 823 with formic acid gave triazolo[3,4-c][ 1,2,4]tri-azine 824 and triazolo[5,l-r][l,2,4]triazine 825 [75BSF(2)864] (Scheme 167). 

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