Tris 3-methylphenyl

Another mechanism of dearylation has been proven for tris(2-methylphen-yl) phosphate, and it is a pathway whose first step must be cytochrome P450 dependent. As shown in Fig. 9.10, the compound is hydroxylated at a Me group to yield the hydroxymethyl analogue 9.46. The latter then breaks down by intramolecular nucleophilic attack to form 2-(2-methylphenoxy)-4//-l,3,2A5-benzodioxaphosphinin-2-one (9.47, Fig. 9.10). This reaction of cy-clization occurs with loss of a ortho-cresyl moiety and is catalyzed by serum albumin [102], The cyclized product is a more potent inhibitor of esterases than tris(2-methylphenyl) phosphate, and it is also more toxic [100][101],... 

Fig. 9.10. Partial metabolic scheme of tris(2-methylphenyl) phosphate (9.44) showing hydrolysis to the diester 9.45, the monoester, and phosphate. Also shown is a reaction of oxidation to the hydroxymethyl analogue 9.46, followed by cyclization to the toxic cyclic phosphate 9.47...

Synonyms AI3-00520 BRN 1892885 CCRIS 6421 o-Cresyl phosphate EINECS 201-103-5 Fyrquel 150 NSC 438 Phosflex 179-C Phosphoric acid, tris(2-methylphenyl) ester Phosphoric acid, tri-2-tolyl ester Phosphoric acid, tri-o-cresyl ester o-TCP TCP TOCP TOFK o Tolyl phosphate TOTP Tricresyl phosphate Triorthocresyl phosphate Tri-2-methylphenyl phosphate Tris(o-cresyl)phosphate Tris(o-methylphenyl)phosphate Tris(o-tolyl)phosphate Tri-2-tolyl phosphate Tri-o-tolyl phosphate. 

Phosphoric acid, triphenyl ester, see Triphenyl phosphate Phosphoric acid, tris(2-methylphenyl) ester, see Tri-o-cresyl phosphate... 

Trimethylnorcamphor, see Camphor Trimethylphenylmethane, see ferf-Butylbenzene Tri-2-methylphenyl phosphate, see Tri-o-cresyl phosphate 1,1,1-Trimethylpropane, see 2,2-Dimethylbutane... 

Polychloroethene (polyvinyl chloride), as usually prepared, is atactic and not very crystalline. It is relatively brittle and glassy. The properties of polyvinyl chloride can be improved by copolymerization, as with ethenyl ethanoate (vinyl acetate), which produces a softer polymer ( Vinylite ) with better molding properties. Polyvinyl chloride also can be plasticized by blending it with substances of low volatility such as tris-(2-methylphenyl) phosphate (tricresyl phosphate) and dibutyl benzene-1,2-dicarboxylate (dibutyl phthalate) which, when dissolved in the polymer, tend to break down its glasslike structure. Plasticized polyvinyl chloride is reasonably flexible and is widely used as electrical insulation, plastic sheeting, and so on. 

Z)-Allyltrimethylsilanes.1 Reaction of aldehydes with 2-trimethylsilylethy-lidinetriphenylphosphorane has been used to convert aldehydes into allyltrime-thylsilanes as a mixture of (E)- and (Z)-isomers (9,492). Replacement of triphen-ylphosphine by tris(2-methylphenyl)phosphine enhances (Z)-selectivity, particularly in reactions with aliphatic saturated aldehydes. These aldehydes can be converted into the (Z)-allylsilanes (Z/E > 94%) with 1, and with use of BuLi at 0° for generation of the phosphorane. 

SYNS o-CRESYL PHOSPHATE PHOSFLEX 179-C PHOSPHORIC ACID, TRI-o-CRESYL ESTER PHOSPHORIC ACID, TRIS(2-METHYLPHENYL) ESTER TOCP TOFK o-TOLYL PHOSPH.ATE TOTP TRICRESAT. PHOSPHATE TRI-o-CRESYL PHOSPHATE... 

To a mixture of tris(2-methylphenyl)bismuth dichloride (2.21 g, 4.15 mmol), trifluoroacetamide (458 mg, 4.05 mmol) and dichloromethane (80 ml) was added potassium fert-butoxide (998 mg, 8.91 mmol) at —50°C. The resulting mixture was allowed to warm gradually to 10°C with vigorous stirring. The insoluble solid was filtered through Celite and the filtrate was concentrated under reduced pressure to leave an oily residue, which was crystallized from dichloro-methane-hexane to give tris(2-methylphenyl)bismuthine A trifluoroacetylimide as a pale yellow solid (2.205 g, 90%), m.p. 108-116°C (decomp.) [99OM2580]. 

PHOSPHORIC ACID, TRIS(2-METHYLPHENYL) ESTER (78-30-8) Combustible liquid (flash point 437°F/225°C). Hydrolyzes in water, forming phosphoric acid. Violent reaction with strong oxidizers. Contact with magnesium may cause explosion. The aqueous solution is incompatible with sulfuric acid, caustics, ammonia, aliphatic amines, alkanolamines, isocyanates, alkylene oxides, epichlorohydrin, nitromethane. Attacks some plastics, rubber, and coatings. 

Tris(2-methylphenyl)phosphine Tris(3-methylphenyl)phosphine Tris(4-methylphenyl)phosphine Tris(2-methyl-2-propenoyl)-2-ethyl-2-hydroxymethyl-1.3-propanediol... 

Synonyms o-Cresyl phosphate Phosphoric acid, tri-o-cresyl ester Phosphoric acid, tris (2-methylphenyl) ester Phosphoric acid, tri-o-tolyl ester TOCP... 

Tri 2-methylphenyl phosphate. See Tri-o-cresyl phosphate Tri methyl phosphate CAS 512-56-1... 

M A7-butyllithium in hexane added to a stirred suspension of [2-(trimethylsilyl)-ethyl]tris(2-methylphenyl)phosphonium iodide in THF at 0°, the mixture stirred at room temp, for 30 min, and a soln. of nonanal in THF added at 0° - product. Y 91 % (E/Z 3.7 100). Replacing a phenyl group in the ylid by o-methylphenyl improves Z-specificity and reduces silyl rearrangement (except with benzaldehyde and cinnam-aldehyde). F.e.s. H. lio et al., Tetrahedron Letters 29, 5965-8 (1988) review of silicon compds. in organic synthesis s. P. Kochs, Chem.-Ztg. 113, 225-38 (1989). 

Tribenzylsilane Dinaphthyl(l )silane Tris(2-methylphenyl)silane... 

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