Tris amine hydrochloride

C. Thiete 1,1-dioxide. A sample of 3-chlorothietane l,l-d1ox1de (8.0 g, 0.057 mol) Is dissolved In dry toluene (300 ml) (Note 7) In a 500-mL, twonecked, round-bottomed flask equipped with a reflux condenser, magnetic stirrer, heating mantle (or silicone oil bath), and thermometer. The reaction Is heated to 60° C and tri ethyl amine (28.7 g, 0.28 mol, 39,5 ml) Is added through the condenser. The reaction mixture Is stirred for 4 hr and triethyl-amine hydrochloride is removed by filtration and washed with toluene (100 mL), Toluene is removed on a rotary evaporator and the residue is recrystallized from diethyl ether-ethanol (Note 8) to give a white solid (4.5-4.8 g, 75-81 ) mp 49-50°C (llt mp 52-54°C). 

Tri-n-octylamine [1116-76-3] M 353.7, b 164-168 /0.7mm, 365-367 /760mm, d 0.813, n 1.450, pK 10.65. It was converted to the amine hydrochloride etherate which was recrystd four times from diethyl ether at -30° (see below). Neutralisation of this salt regenerated the free amine. [Wilson and Wogman J Phys Chem 66 1552 1962.] Distd at l-2mm pressure. 

Non-geminal bis, tris, and tetrakis secondary amino derivatives are found to undergo reversible cis trans isomerisations in the presence of amine hydrochlorides [141-145]. It is reported that aluminium trichloride also acts as a catalyst for these interconversions (Eq. 26) [142]. 

Nitrogen mustards include HNl [bis(2-chloroethyl) ethylamine], HN2 (2,2 -dichloro-V-methyldiethylamine), and HN3 [tris(2-chloroethyl)amine hydrochloride]. As will be discussed later, some of these found application in therapeutic arenas rather than in warfare. 

Goodman, L.S., Wintrobe, M.M., Dameshek, W., Goodman, M.J., Gilman, A., McLennan, M.T. (1984). Landmark article Sept. 21, 1946 nitrogen mustard therapy. Use of methyl-bis(beta-chloroethyl)amine hydrochloride and tris(beta-chloroethyl)-amine hydrochloride for Hodgkin s disease, lymphosarcoma, leukemia and certain allied and miscellaneous disorders. JAMA 251 2255-61. 

Ruff et al. in a series of publications described the synthesis of amine complexes of aluminum hydride [32, 33]. Their study investigated the reaction of these materials with typical Lewis bases in order to define the conditions for the stability of aluminum hydride derivatives in which the aluminum atom exhibits a coordination number of five. They first described methods for making tertiary alkyl amine complexes of aluminum hydride utilizing lithium aluminum hydride and an amine hydrochloride. A finely ground lithium aluminum hydride was placed together with trimethylammonium chloride (ratio 1 2). They prepared other trialkylamine alanes and the N-dialkylaminoalanes, in a similar fashion. These adducts of alane were found to sublime readily at temperatures up to 40 °C except for the tri-n-propylamine alane, which sublimed very slowly and could also be recrystallized from hexane at — 80 °C. 

SYNS LEKAXnN NSC-30211 R-47 SINALOST SK-100 TRICHLORMETHINE TRICHLORMETH-INIUM CHLORIDE TRI(P CHLOROETHYL)AMINE HYDROCHLORIDE TRI-(2-CHLOROETHYL)AMINE HYDROCHLORIDE 2,2 ,2 -TRICHLOROTRIETHYLAM-INE HYDROCHLORIDE TRICHLOR-TRIAETHYLAM-IN-HYDROCHLORID (GERMAN) TRILLEKAMIN TRIAOTAN TRIML STINE TRIMUSTINE HYDROCHLORIDE TRIS(P-CHLOROETHYL)AMINE HYDROCHLORIDE TRIS(2-CHLOROETHYL)AMINE HYDROCHLORIDE TRIS(2-CHLOROETHYL)AAaNE MONOHYDROCHLORIDE TRIS-N-LOST TS-160... 

TRICHLORO-l, 1-ETHANEDIOL see CDOOOO TRICHLOROETHANOIC ACID see TII250 TRICHLOROETHENE see TIO750 TRICHLOROETHENYLSILANE see TIN750 TRI-(2-CHLOROETHYL)AMINE HYDROCHLORIDE seeTNF500... 

Mechanistic Studies. - The mechanism of the reaction of tetra-zole-activated phosphoramidites with alcohols has been studied. A series of diethyl azolyl phosphoramidites (85) was prepared from diethyl phosphorochloridite and fully characterized, and the same compounds shown to be formed from the phosphoramidite (86) and azole. The degree of formation of (85) from (86) increases with the acidity of the azole, and the proposed mechanism is a fast protonation of (86), followed by a slow, reversible formation of (85) and a fast reaction of (85) with alcohols. Another study was concerned with the influence of amine hydrochlorides on the rate of methanolysis of the phosphoramidites (87) or (88), or tris(diethylamino)phosphine.The chloride content was measured to be 10-20 mM in doubly distilled samples which explains that "uncatalysed alcoholysis is possible. Intensive purification, including treatment with butyllithium and distillation from sodium, brought the chloride content down to 0.1-1 mM. The methanolysis reaction, in methanol as the solvent, was found to be first-order in catalyst concentration. An aJb initio calculation on N- and P-protonated aminophosphine (89) gave similar proton affinities for N and P this contrasts with earlier MNDO calculations which had ff-protonated species as the most stable. The M-protonated compound had an electronic structure reminiscent of a phosphenium ion-ammonia complex. 

Hydroboration of tris(2-methylallyl)amine hydrochloride gave the tricyclic product (62) (16%) (Equation (9)). The two diastereomers of (62) were separated by either HPLC or GC <85JA590l>. 

The monomer tri-isocyanto-trimethyl-borazine (TITMB) was synthesized from trichloro-trimethyl-borazine (TCTMB) according to the method reported in the literature [12]. The Intermediate TCTMB was synthesized via a modification of the procedure of Brown and Laubengayer [13]. Methyl-amine hydrochloride and excess of BCI3 were refluxed in chlorobenzene for 6h and then maintained for 16h at 80°C. The reaction mixture was filtered warm, vacuum dried and subsequently sublimed under reduced pressure. A slight increase in yield (12%) of pure TCTMB was achieved. 

CAS 637-39-8 EINECS/ELINCS 211-284-2 Synonyms 2,2, 2"-Nitrilotris [ethanol], hydrochloride Triethanolamine hydrochloride Tris (hydroxyethyl) amine hydrochloride Tris (2-hydroxyethyl) ammonium chloride Classification Salt Empirical CeHisNOs CIH Formula (HOCH2CH2)3N HCI Properties Wh. cryst. powd. m.w. 185.65 m.p. 178-179 C... 

Tris (hydroxyethyl) amine hydrochloride Tris (2-hydroxyethyl) ammonium chloride. See TEA-hydrochloride... 

T. P. Dawson, W. J. H. B. Wells, and C. W. MacFarlan, Prepatation and Vesicant Action of Tris(B-chloroethyl)amine and Tris(B-chloroethyl)amine Hydrochloride. EATR 281, 22 Mar 39. 

Synon5ms Tris(-chloroethyl)amine [tris(2-chloroethyl)amine hydrochloride] ... 

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