Trimethoprim dosing

Streptococcus gentamicin (5 mg/kg per day, dosing based on serum levels) Alternative Therapies Trimethoprim-sulfamethoxazole (TMP-SMX) 10-20 mg/kgTMP IV per day in divided doses every 6-8 hours or meropenem Standard Therapy TMP-SMX Rash, Stevens-Johnson syndrome, bone marrow suppression, nausea/vomiting, hepatotoxicity 14-21... 

Trimethoprim- sulfamethoxazole 8-10 mg/kg per day of trimethoprim component in 2 doses Nausea, vomiting, anorexia, rash, urticaria S Increasing pneumococcal resistance contraindicated in children under 2 months... 

Trimethoprim-sulfamethoxazole (or trimethoprim alone) is a second-line oral agent that may be used for patients who do not tolerate tetracyclines and erythromycin or in cases of resistance to these antibiotics. The adult dose is usually 800 mg sulfamethoxazole and 160 mg trimethoprim twice daily. 

Antibiotics shorten the duration of diarrhea, decrease the volume of fluid lost, and shorten the duration of the carrier state (see Table 39-3). A single dose of oral doxycycline is the preferred agent. In children younger than 7 years of age, trimethoprim-sulfamethoxazole, erythromycin, and furazolidone can be used. In areas of high tetracycline resistance, fluoroquinolones are effective. 

Vibrio cholerae 01 or Doxycydine 300 mg oral single dose tetracycline 500 mg orally four times daily x 3 days or trimethoprim-0139 sulfamethoxazole DS tablet twice daily x 3 days norfloxacin 400 mg orally twice daily x 3 days or... 

Trimethoprim-sulfamethoxazole is given in doses of 15 to 20 mg/kg/day (based on the trimethoprim component) as three to four divided doses for the treatment of PCP. Treatment duration is typically 21 days but must be based on clinical response. 

Trimethoprim-sulfamethoxazole IV or orally 15-20 mg/kg/day as trimethoprim component in 3-4 divided doses for 21 days0 (Al) or... 

Trimethoprim-sulfamethoxazole is the preferred therapy for both primary and secondary prophylaxis of PCP in adults and adolescents. The recommended dose in adults and adolescents is one double-strength tablet daily. 

Trimethoprim-sulfamethoxazole 4-6 mg/kg (of the trimethoprim component) every 12 hours + metronidazole 30 mg/kg in three to four divided doses or clindamycin 10-30 mj kj day in three to four divided doses0... 

DS, double strength SS, single strength TMP, trimethoprim TMP-SMX, trimethoprim-sulfamethoxazole. °Dosing internals for normal renal function. 

Acute uncomplicated cystitis Escherichia coli Staphylococcus saprophyticus 1. Trimethoprim-sulfamethoxazole x 3 days (A, 1)° 2 Fluoroquinolone x 3 days (A II)0 3. Nitrofurantion x 7 days (B, l)° 4. /)Lactams x 3 days (E, III)0 Short-course therapy more effective than single dose /J-factams as a group are not as effective in acute cystitis than trimethoprim-sulfamethoxazole or the fluoroquinolones0... 

Short-course therapy (3-day therapy) with trimethoprim-sulfamethoxazole or a fluoroquinolone (e.g., ciprofloxacin, levofloxacin, or norfloxacin) is superior to single-dose therapy for uncomplicated infection and... 

Single-dose or short-course therapy with trimethoprim-sulfamethoxazole has been used effectively, and prolonged courses of therapy are not necessary for the majority of patients. 

In women who experience symptomatic reinfections in association with sexual activity, voiding after intercourse may help prevent infection. Also, self-administered, single-dose prophylactic therapy with trimethoprim-sulfamethoxazole taken after intercourse has been found to significantly reduce the incidence of recurrent infection in these patients. 

Tetracycline, 40 mg/kg/day in three divided oral doses. Trimethoprim/sulfa (TMP), four mg per kg per day/sulfa, 20 mg per kg per day in divided oral doses. 

Urinary tract infections and shigellosis 8-10 mg/kg daily based on trimethoprim in 3 equal doses (q8h by IV infusion) for 7 days. 

Septra IV Antibiotic Inj per 5 mL Sulfamethoxazole 400 mg, trimethoprim 80 mg P carinii pneumonia 15 mg/l day (based on TMP) IV in 3 doses x 21 days (each dose in 250 mL of D5Wover 2 hours). Urinary tract infections and shigellosis 8-10 mg/kg daily based on trimethoprim in 3 equal doses (q8h by IV infusion) for 7 days. 

Benazepril (Lotensin) [Antihypertensive/ACEI] Uses HTN DN, CHF Action ACE inhibitor Dose 10 0 mg/d PO Caution [C (1st tri), D (2nd 3rd tri), +] Contra Angioedema, Hx edema, bilateral RAS Disp Tabs 5, 10, 20, 40 mg SE Symptomatic i BP w/ diuretics dizziness, HA, nonproductive cough Interactions T Effects W/ a-blockers, diuretics, capsaicin effects W/ NSAIDs, ASA T effects OF insulin, Li T risk of hyperkalemia W/ trimethoprim K-sparing diuretics EMS Monitor EGG for signs of hyperkalemia angioedema is rare but can occur persistent cough /or taste changes may develop OD Profound hypotension treat w/ IV fluid... 

Mercaptopurine [6-MP] (Purinethol) [Antineoplastic/ Antimeta lite] Uses Acute leukemias, 2nd-line Rx of CML NHL, maint ALL in children, immunosuppressant w/ autoimmune Dzs (Crohn Dz) Action Antimetabolite, mimics hypoxanthine Dose Adults. 80-100 mg/mVd or 2.5-5 mg/kg/d maint 1.5-2.5 mg/kg/d Peds. Per protocol X w/ renal/hepatic insuff on empty stomach Caution [D, ] Contra Severe hepatic Dz, BM suppression, PRG Disp Tabs SE Mild hematotox, mucositis, stomatitis, D rash, fever, eosinophilia, jaundice. Hep Interactions T Effects W/ allopurinol T risk of BM suppression W/ trimethoprim-sulfamethoxazole X effects OF warfarin EMS May falsely T glucose OD May cause NA and liver necrosis symptomatic and supportive Meropenem (Merrem) [Antibiotic/Carbapenem] Uses lntra-abd Infxns, bacterial meningitis Action Carbapenem X cell wall synth, a [3-lactam Dose Adults. 1 to 2 g IV q8h Peds. >3 mo, <50 kg 10-40 mg/kg IV q 8h in renal insuff Caution [B, ] Contra [3-Lactam sensitivity Disp Inj 500 mg, 1 g SE Less Sz potential than imipenem D, thrombocytopenia Interactions T Effects W/ probenecid EMS Monitor for signs of electrolyte disturbances and... 

---