Trihydrochloride

Spermidine trihydrochloride [334-50-9] M 245.3, m --250°(dec), 256-258", for pKa see free base above. Recrystd from dry 3% HCl in ethanol adding dry Et20 if necessary. Filter rapidly and dry in a vac desiccator. Alternatively centrifuge the crystals off wash them with dry Et20 and dry in a vacuum. 

Spermine 4HC1 (7V,7V-bis(3-aminopropyl)-l,4-butanediamine 4HC1) [306-67-2] M 348.2, m 313-315". The pKs are similar to spermidine above. Purification as for spermidine trihydrochloride above. 

Tris-(2-aminoethyl)amine trihydrochloride [14350-52-8] M 255.7, m 300 (dec). Crystd several times by dissolving in a minimum of hot water and precipitating with excess cold EtOH. The ppte was washed with acetone, then diethyl ether and dried in a vacuum desiccator. 

Extension of these studies to medium rings produced interesting results (73). The mercuric acetate oxidation of 1-methyl-1-azacyclooctane (64), when worked up in the usual manner, gave no distillable material. When an equivalent amount of hydrochloric acid was added to the solution which had been saturated with hydrogen sulfide to precipitate the excess mercuric acetate and filtered, evaporation of the solution to dryness gave a solid which was subsequently identified as 2,4,6-tris(6 -methylaminohexyl)-trithiane trihydrochloride (65). Two plausible routes to the observed... 

Catalytic hydrogenation (Pd/C) of 2-chloro-3-nitro-l,5-naphthyridine (125, R = Cl) in methanolic solution afforded 3-amino-l,5-naphthyridine (126, R = H, 74%) isolated in the form of its trihydrochloride (40MI1). Similar Pd/C hydrogenation of 2-ethoxy-3-nitro-l,5-naphthyridine (125, R = OEt) gave 3-amino-2-ethoxy-l,5-naphthyridine (126, R = OEt, 47%) (80RTC83). Reduction with tin(II) chloride in hydrochloric acid also leads to 126, (R = OEt, 73%) (63RTC997). 

When prepared by regeneration from the trihydrochloride, the sesquiterpene is inactive, a pure specimen having the following characters —... 

If a current of hydrochloric acid gas be passed through an ice-cold solution of the sesquiterpene dissolved in ether a crystalline trihydrochloride is obtained, which melts at 79° to 80°, and has the formula C15H24.3HC1. 

L-Asperaginyl-L-arginyl-L-velyl-L-tyrosyl-L-velyl-L-hlstIdyl-L-prolyl-L-phenylelenine methyl ester trihydrochloride Sodium hydroxide... 

L-Asparaginyl-L-arginyl-L-valyl-L-tyrosyl-L-valyl-L-histidyl-L-prolyl-L-phenylalanine methyl ester trihydrochloride Angiotensin amide Atropic acid ethyl ester Tilidine HCI Atropine... 

C1H9NO 156-87-6) see Acamprosate calcium Cyclophosphamide Dexpanthenol Domperidone Gusperimus trihydrochloride Mefenorex Urapidil 7-amino-3-[(Z)-l-propenyl]-3-cephem-4-carboxylic acid (CiqHi2N203S 106447-44-3) see ci s-Cefprozil 3-aminopropionaIdehyde diethyl acetal (C7H,7N02 41365-75-7) see Atorvastatin calcium P-aminopropionic acid phosphite (C3H, N0 P) see Pamidronic acid... 

C4H,2N2 110-60-1) see Gusperimus trihydrochloride butanedioic acid 2-(dimethylamino)ethyl (2,2,8-trimethyl-47/-l,3-dioxino[4,5-c]pyridin-5-yl)methyl ester (CicjHjjNjO 98298-58-9) see Pirisudanol butanedioic acid mono[2-(dimethylamino)ethyl] ester (CsH,5N04 10549-59-4) see Pirisudanol butanedioic acid mono(2-oxo-l,2-diphenylethyl) ester (C,8Hi(,05 24248-42-8) see Oxapfozin... 

C15H21NO5) see Gusperimus trihydrochloride 4-[hydroxy[5-[[(phenylmethoxy)carhonyl]amino]pen-tyl]amino]-4-oxobutanoic acid (C,7H24N20ft 106410-46-2) see Deferoxamine D-a-(4-hydroxyphenyl)-tx-(2-methoxycarbonyl-l-methyl-cthenylamino)acetic acid anhydride with monoethyl carbonate... 

C6H14N2O2 56-87-1) see Eptifibatide Gusperimus trihydrochloride Ibuprofen lysinate Lisinopril Lymecycline... 

C2CI2O2 79-37-8) see Cefuroxime Diclofenae Dorzolamide Fexofenadine hydroehloride Granisetron Gusperimus trihydrochloride Indoramin Maprotiline Micinicate Ritonavir Saquinavir Sumatriptan Tacrolimus Tirofiban hydrochloride Tropisetron Viminol... 

C7H7CIO2S 98-59-9) see Benproperine Brinzolamide Carzenide Cefoxitin Diazepam Flurotyl Fosinopril Gusperimus trihydrochloride Idarubicin Idoxuridine Indeloxacine Levocabastine Mazindol Medazepam Mibefradil hydrochloride Nemonapride Pioglitazone Prenalterol Ropinirole Tinidazole Tolterodine p-toluenesulfonamide... 

Hufford et al [13] used a 13C NMR spectroscopic method for the assignments of dissociation constants of primaquine. The first and second dissociation constants of primaquine were determined by titration with 0.1 N hydrochloric acid in acetonitrile-water mixtures and values were extrapolated to water by using linear regression analysis. The assignments of the dissociation constants were unambiguously achieved by studying the 13C NMR spectral data obtained with monohydrochloride, dihydrochloride, and trihydrochloride salts. 

From Sigma 3-aminoethylcarbazole (AEC) acrylamide/bis-acrylamide (30%) 37.5 1 amino acids alumina bentonite benzamidine bovine fiver tRNA bovine serum albumin (BSA) creatine phosphate (CP) diethyl pyrocarbonate (DEPC) dithiothreitol (DTT) Escherichia coli MRE600 tRNA pyrophosphatase (Ppase) Ca++ salt of folinic acid, (5-formyl THF) IIHPHS K salt of phospho-enol pyruvic acid, (PEP) creatine phospho kinase (CPK) protease inhibitor cocktail for fungal and yeast extracts phenylmethylsulfonyl fluoride (PMSF) spermidine trihydrochloride Tween 20. 

Triaminopropane trihydrochloride [free base 21291-99-6J M 198.7, m 250°. Cryst from EtOH. 

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