Trigger Selection

The events of interest are selected by the HLT Mu3 single muon trigger path (see Sect. 4.3). The trigger efficiency is measured from data in minimum bias events. The minimum bias events were obtained as described in Sect. 5.1 and the HLT Mu3 efficiency is calculated by 

The trigger efficiency as a function of muon transverse momentum and pseudorapidity is shown in Fig. 6.2. It should be noted that the MC simulation overestimates the trigger efficiency. 

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C arbohydrate-remodelled gluco cerebro sidase Enzymatic removal of sialic acid caps exposes mannose residues, triggering selective product uptake by macrophages (the target cell type) 12... 

Yin HZ, Weiss JH (1995) Zn(2-l-) permeates Ca(2+) permeable AMPA/kainate channels and triggers selective neural injury. NeuroReport 6 2553-2556 Yokoyama M, Koh J, Choi DW (1986) Brief exposure to zinc is toxic to cortical neurons. Neurosci Lett 71 351-355... 

Dumanchin-Njock, C., Alves da Costa, C., Mercken, L., Pradier, L., Checler, F. (2001) The caspase-derived C-terminal fragment of 6APP induces caspase-independent toxicity and triggers selective increase of A642 in maimnalian cells J. Neurochem. 78,1153. 

In order to be successful as part of a medical device a polymer has to resist both biological rejection by the patient s body and degradation. The human body is an enviromnent which is simultaneously hostile and sensitive, so that materials for application in medicine must be carefully selected. The essential requirement is that these materials are biocompafible with the particular part of the body in which they are placed. The extent to which polymers fulfil this requirement of biocompafibility depends partly on the properties of the polymer and partly on the location in which they are expected to perform. For example the requirements for blood biocompafibility are stringent since blood coagulation may be triggered by a variety of materials. By contrast, the requirements for materials to be used in replacement joints in orthopaedic surgery are less severe and materials as diverse as poly (methyl methacrylate) and stainless steel can be used with minimal adverse reaction from the body. 

There is, however, a unique risk in the bipolar form that antidepressant treatment may trigger a switch into mania. This may occur either as the natural outcome of recovery from depression or as a pharmacological effect of the drug. Particular antidepressants (the selective serotonin reuptake inhibitors) seem less liable to induce the switch into mania than other antidepressants or electroconvulsive therapy. Treatment for mania consists initially of antipsychotic medication, for instance the widely used haloperidol, often combined with other less specific sedative medication such as the benzodiazepines (lorazepam intramuscularly or diazepam orally). The manic state will usually begin to subside within hours and this improvement develops further over the next 2 weeks. If the patient remains disturbed with manic symptoms, additional treatment with a mood stabilizer may help. 

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