Trifluoromethylsulfonylation

A long series of studies of aromatic nucleophilic substitution included the kinetics of reactions of l-chloro-2,4-bis(trifluoromethylsulfonyl)benzene, 3-nitro-4-chlorophenyl trifluoromethyl sulfone and 2-chlorophenyl trifluoromethyl sulfone with sodium methox-ide or ammonia in methanol . The SO2CF3 group was found to have an enormous accelerating effect, in accord with the value of 1.65, based on the dissociation of anilinium ion. Further examples of the promotion of nucleophilic aromatic substitution by fluoro-substituted sulfonyl groups are given by Yagupol skii and coworkers . 

Whereas, Goharshadi et al. [16] have synthesized the ZnO nanoparticles of 60 nm (Fig. 8.4.) using a room temperature ionic liquid, l-hexyl-3-methylimidazolium bis (trifluoromethylsulfonyl)imide, Formation of ZnO was not observed when the ionic liquid was replaced by water. Also, in the absence of ultrasound, formation of ZnO was not observed which is very similar to the one as proposed in the previous case of ZnO dendritic nanostructures. 

Further progress [12] in this field focused on developing the aforementioned trifluoromethylsulfonyl substituted oxamides [10], Of the numerous molecules synthesized and tested, 4,4 - oxalyl to[(trifluoromethylsulfonyl)imino]-ethylene z y(4-methylmorpholinium trifluoromethansulfonate) (METQ) and 2,2 - oxalyl - z y[(trifluoromethanesulfonyl)imino]ethylene - bis(iV- methylpyridi -nium) trifluoromethanesulfonate (PETQ) (see Fig. 3) were found to be the most... 

Figure 3 Structures of 4,4 - oxalyl fe[(trifluoromethylsulfonyl)imino]-ethylene f>is (4-methylmorpholinium trifluoromethansulfonate) (METQ) and 2,2 -oxalyl-Ws,[(triflu-oromethanesulfonyl)imino]ethylene-te(lV-methylpyridinmm) trifluoromethanesulfonate (PETQ).

Liquid chromatography-electrogenerated chemiluminescence Lithium diisopropylamide Low-density lipoprotein Laser-induced fluorescence Limit of detection Monoclonal antibody Maximum admissible concentration l,2-B (3-chlorophenyl)ethylenediamine Micellar electrokinetic chromatography 4,4 - Oxalyl 6 [(trifluoromethylsulfonyl)imino]-ethylene 6 (4-methylmorpholinium)trifluoromethanesulfonate Maltose phosphorylase Multipinned phase... 

Oxalyl- z s[(trifluoromethylsulfonyl)imino]trimethylene-6 ( V-methylmorpholinium) trifluoromethanesulfonate and 4,4 - Oxalyl-to[(trifluoromethylsulfonyl)imino]-trimethylene to(4-methylmorpholinium) trifluoromethanesulfonate Mass spectrometry... 

The invention of the triflate (trifluoromethylsulfonyl) group — one of the world s best leaving groups — has led to its use in palladium chemistry [42]. Conway and Gribble described the synthesis of 3-indolyl triflate 34 [12] and 2-indolyl triflate 35 from oxindole [43]. Mdrour synthesized the N-phenylsulfonyl derivative 36 by employing a Baeyer-Villiger oxidation of the appropriate indolecarboxaldehyde [44],... 

A-(Trifluoromethylsulfinyl)trifluoromethyliniidosulfinyl azide, 0640 Trifluoromethylsulfonyl azide, 0348 l,3,5-Tris(4-azidosulfonylphenyl)-l,3,5-triazinetrione, 3818... 

Palladium catalyzed cross coupling of arylboronic acid to nonracemic trifluoromethylsulfonyl and fluorosulfonyl enol ethers is one of the key steps in the synthesis two endothelin receptor antagonists, SB 209670 and SB 217242, which have been clinically evaluated for several illnesses including hypertension, ischemia, stroke and others [37] (Scheme 6.14). 

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