Triethyleneglycol dimethyl ether

To the flask containing the crude product, add 2.0 g (0.02 mol) of maleic anhydride and 25 ml of triethyleneglycol dimethyl ether ( triglyme , b.p. 222 °C), fit a reflux condenser and boil under reflux for 10 minutes over a Bunsen flame. Cool the solution to about 100°C, add 10ml of 95 per cent ethanol and pour into a solution of 3.0 g of sodium hydroxide in 75 ml of water. Stir for a few minutes, then cool in ice-water and filter under suction. Wash the residue with chilled methanol/water (4 1 v/v) and recrystallise from methylcyclohexane or a chloroform/methanol mixture to give colourless plates of 9-bromotriptycene, m.p. 251-256 °C yield is 1.5 g (45%). Further recrystallisation gives the pure product, m.p. 258-262 °C. 

Determination of signs of intoxication Muscimol in physiological saline and abamectin in triethyleneglycol dimethyl ether were administered to mice by intraperitoneal (IP) injection (50 yl of vehicle) or intracerebral injection as described by Lawrence and Casida (18 1-3 yl of vehicle). Animals were observed after dosing for the appearance of excitatory or depressant signs of intoxication. 

A lipase has been used to convert solid triolein (glycerol trioleate) to the monooleate by treatment with glycerol at 8°C.75 Other lipases have been used in the hydrolysis and transesterification of oils, as well as in the esterification of fatty acids without solvents.76 Peptides can be produced from eutectic mixtures of amino acid derivatives with the addition of a small amount of solvent.77 Immobilized sub-tilisin and thermolysin were used with 19-24% water or an alcohol to produce polypeptides. Subtilisin on celite (a di-atomaceous earth) was used to convert a mixture of L-phenylalanine ethyl ester and L-leucinamide containing 10% triethyleneglycol dimethyl ether to L-phenylala-nineleucinamide in 83% yield. Addition of 30% 2 1 ethanol/water reduced the time needed from 40 to 4 h. The enzyme could be used three more times. These reaction mixtures contained 0.13-0.75 g peptide per g reaction mixture compared with 0.015-0.035 when the reaction was... 

The carbon-zinc bond is fairly robust toward thermal and even hydrolytic stress. (Z)-l,2,3,3,3-Pentafluoro-l-iodopropene can be readily prepared by metalation of ( )-l,2,3,3,3-pentafluoropropene (with n-butyllithium in DEE and THF) and subsequent iodination. But its isolation is compromised by the low boiling range of the product (bp 55-57 °C), what renders the separation from the solvent difficult. A detour via the thermally less sensitive zinc analog circumvents this obstacle. All volatiles can now be completely evaporated before the residue is taken up in triethyleneglycol dimethyl ether ("triglyme," bp 215-217 °C) and molecular iodine is added (Scheme 1-13). ... 

S,S)-2,3-Butanediol (see Section 4.1.2. for access to this compound) was the starting material for the synthesis of (S,S)-2,3-dimethyl-18-ciown-6 (6) which has been used as a chiral catalyst in the enantioselective Michael addition reaction (Sections D.1.5.2.1. and D.I.5.2.4.). Chain elongation of the diol by reaction with ethyl diazoacetate and lithium aluminum hydride reduction, followed by cyclization with triethyleneglycol ditosylate, gives the crown ether 610. 

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