Triethyl phosphonoformate

Triethyl phosphonoformate was prepared by the dropwise addition of ethyl chloroformate (10.85 g, 0.1 mol) to triethyl phosphite (16.6 g, 0.1 mol) with vigorous stirring at ambient temperature. After the... 

To the resultant triethyl phosphonoformate (105 g, 0.5 mol) was added sodium hydroxide solution (250 ml, 10 M) over a period of 15 min at ambient temperature. The solution became hot, and ethanol by-product boiled off from the reaction mixture. Upon cooling, a precipitate formed, which was recrystallized from water to give colorless crystals of the pure trisodium phosphonoformate hexahydrate (27.5 g, 19%), which exhibited IR and NMR spectra and x-ray crystal analysis in accord with the proposed structure. 

The wet substance is recrystallized in 570 ml of water by heating to 423 g (4.77 mol) of sodium hydroxide liquid cone, is added to 400 ml of water. The solution is heated to about 50°C and 167 g (0.795 mol) of triethyl phosphonoformate is added at this temperature. The reaction mixture is then heated to about 90°C and ethanol formed is distilled off. After about 1 hour at 90-95°C the reaction mixture is cooled to about 20°C and the product is filtered off. The yield of trisodium phosphonoformate hexahydrate wet is 248... 

Triethyl phosphonoformate is hydrolyzed in alkaline solution to give a crystalline trisodium salt as a hexahydrate (Scheme 8.4). " - Treatment of hEftrimethylsilyl) (alkoxycarbonyl)phos-phonates with NaOH has also been reported. In acid solution the phosphonofonnic acid decar-boxylates rapidly." " ... 

Triethyl phosphonoformate served as a tool for the introduction of the ethoxycarbonyl group into the cyclopentanedione ring (a) for the purpose of activation of a position and (b) as a one-carbon unit for building up a side-chain (equation 62) ... 

TEPA. See Tetraethylenepentamine TEPA. See Triethyl phosphonoacetate TEPF. See Triethyl phosphonoformate Tephaprint RV. See Sodium polyacrylate Tephasoft CT-W. See Silicone TEP-HP. See Triethyl phosphite TEPP. See Tetraethyl pyrophosphate Tequat BC. See Cetrimonium chloride Tequat PAN. See Lauralkonium chloride Terathane 650r, Terathane 1000] Terathane ... 

Triethyl phosphonoformate CAS 1474-78-8 EINECS/ELINCS 216-016-8 Classification Nonaromatic phosphorus compd. Empirical C7H15O5P... 

Triethyl phosphine Triethyl phosphite Triethyl phosphonoacetate Triethyl phosphonoformate Triisopropyl phosphite 3,4,5-Trimethoxybenzoyl chloride 1,2,4-Trimethyl benzene 2,4,6-Trimethylbenzoyldiphenylphosphine oxide Trimethyl phosphite Tripropylene glycol Urethane n-Valeric acid Vinyl bromide p-Xylene D(+)-Xylose intermediate, pharmacologicals... 

Triethyl phosphonoformate 216-032-5 m-Xylylenediamine 216-074-4 Menthol 216-087-5 Fluorad FC-24 Trifluoromethane sulfonic acid 216-116-1 Methyl glutarate 216-120-3... 

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