Triethyl methanetricarboxylate

Ethyl 7-hydroxy-3-methyl-5-oxo-2,3-dihydro-5//-pyrido[l, 2,3- /e]-1, 4-benzoxazine-6-carboxylate was obtained by cyclocondensation of 3-methyl-3,4-dihydro-2//-l,4-benzoxazine and triethyl methanetricarboxylate (00MI3). 

Cyclocondenzation of l-methyl-l,2,3,4-tetrahydroqunoxalines and triethyl methanetricarboxylate at 150°C for 2h, than at 200 °C for 6h gave 7-hydroxy-l-methyl-5-oxo-2,3-dihydro-5//-pyrido[l,2,3-<7e]quinoxa-lines (OOMIPIO). 

This dendrimer class is a special example of a heterogeneous series. It possesses branch cells derived from the branch cell reagents triethyl methanetricarboxylate and aminotris(hydroxymethyl)methane. In the present case, a tri-dendron dendrimer with Nb = 3 is obtained by advancement through an alkylation stage and... 

Carbethoxylations of esters and nitriles are also effected by treating their enolates with ethyl chlorocarbonate (ethyl chloroformate), ClCOjCjHj. In this manner, triethyl methanetricarboxylate, CH(COjCjHj)j, is prepared from malonic ester through the magnesium enolate. ... 

C10H15NO2 (3S-cisH+)-2,3-dihydro-3-isopropyl-7a-melh 116910-11-3 42.50 1.1450 2 20536 ClOH1606 triethyl methanetricarboxylate 6279-86-3 16.00 1.1084 1... 

Finally, anionic surface dendrimers have been constructed as balloons attached along a Merrifield resin backbone.48 Using an elaboration method based on the diethyl malonate and triethyl methanetricarboxylate procedures previously described,61 dendrimers bearing double and triple branching hydrocarbon arms were prepared with carboxylate termini. These dendrimers are insoluble in all ordinary solvents and serve as high-capacity cation-exchange materials. 

C-Alkylations. Triethyl methanetricarboxylate is readily alkylated by alcohols. Propargylic alcohols are homologated to give 3-alkynenitriles with acetone cyanohydrin to supply the cyano group. ... 

Oxidatively generated electrophilic malonyl radicals react regiospecifically with thiophene to form (2-thienyl)malonic ester <88H(27)2627>. Treatment of thiophene with cerium(IV) sulfate and an excess of dimethyl malonate in methanol at room temperature yields 2-thienylmalonic ester in 85% yield. In this case, the initially formed cr-radical is oxidized by the cerium(IV) sulfate. 2-Methylthiophene similarly gives the 5-malonyl-substituted product. Benzo[i]thiophene leads to the 2-malonyl-benzo[Z)]thiophene in 41% yield. Monosubstituted malonates could also be used in this reaction. Thiophene and 2-acetylthiophene react with triethyl methanetricarboxylate in the presence of Mn(III) to form the corresponding thienylmethane tricarboxylic esters. Yields are about 55% <91S567>. 

Methanetricarboxylic Acid.—Mulliken1 employed the method, which has already been discussed (p. 104), in the electrolysis of the sodium salt of the triethyl ester of this acid and obtained othanehexacarboxylic ester, besides some malonic ester. Further oxidation caused the formation of sodium bicarbonate ... 

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