1,2,3-Triazoles, 1 -aryl-4-

Scheme 4 Triazole arylation under microwave irradiation...

Scheme 5 Triazole arylation under conventional heating...

AAMonosubsti luted triazole arylation resulted in product mixture. Arylation of 1,5-disubstituted triazole afforded the product in low yield consistent with results reported by Yorimitsu. 

In peptide syntheses, where partial racemization of the chiral a-carbon centers is a serious problem, the application of 1-hydroxy-1 H-benzotriazole ( HBT") and DCC has been very successful in increasing yields and decreasing racemization (W. Kdnig, 1970 G.C. Windridge, 1971 H.R. Bosshard, 1973), l-(Acyloxy)-lif-benzotriazoles or l-acyl-17f-benzo-triazole 3-oxides are formed as reactive intermediates. If carboxylic or phosphoric esters are to be formed from the acids and alcohols using DCC, 4-(pyrrolidin-l -yl)pyridine ( PPY A. Hassner, 1978 K.M. Patel, 1979) and HBT are efficient catalysts even with tert-alkyl, choles-teryl, aryl, and other unreactive alcohols as well as with highly bulky or labile acids. 

The reactions of enamines as 1,3-dipolarophiles provide the most extensive examples of applications to heterocyclic syntheses. Thus the addition of aryl azides to a large number of cyclic (596-598) and acyclic (599-602) enamines has led to aminotriazolines which could be converted to triazoles with acid. Particular attention has been given to the direction of azide addition (601,603). While the observed products suggest a transition state in which the development of charges gives greater directional control than steric factors, kinetic data and solvent effects (604-606) speak against zwitterionic intermediates and support the usual 1,3-dipolar addition mechanism. 

A similar procedure was developed in greater detail by Domow and Heiberg. They proceeded from aryl or aralkyl azid and cyanacetamide (176) and the 1-aryl- or l-aralkyl-5-amino-i -triazole-... 

Cyclization of the 5-(A -arylcarboxamido)-4-hydrazino-6methylpyrim-idin-2-ones 104 with two molar equivalents of formaldehyde in the presence of pyridine caused the concomittant triazole and pyrimidine ring formation to yield the 4-aryl-l,3,4,10-tetrahydro-6-methyl-l,2,4-tria-zolo-[2,3,4-c,d]pyrimido[4,5-d]pyrimidine-5,8-diones 105 (89AP599)... 

Diacetylenic lotsitch reagents with azides (THF, 15-18°C, 20 h) afford l-alkyl(aryl)-5-ethynyl-l,2,3-triazoles (94) in 48-70% yield(67ZOR2241). These... 

Abbreviations aapy, 2-acetamidopyridine Aik, alkyl AN, acetoniuile Ar, aryl Bu, butyl cod, 1,5-cyclooctadiene COE, cyclooctene COT, cyclooctatetraene Cp, cyclopentadienyl Cp , penta-methylcyclopentadienyl Cy, cyclohexyl DME, 1,2-dimethoxyethane DME, dimethylformamide DMSO, dimethyl sulfoxide dmpe, dimethylphosphinoethane dppe, diphenylphosphinoethane dppm, diphenylphosphinomethane dppp, diphenylphosphinopropane Et, ethyl Ec, feirocenyl ind, inda-zolyl Me, methyl Mes, mesitylene nb, norbomene orbicyclo[2.2.1]heptene nbd, 2,5-norbomadiene OTf, uiflate Ph, phenyl PPN, bis(triphenylphosphoranylidene)ammonium Pi , propyl py, pyridine pz, pyrazolate pz, substituted pyi azolate pz , 3,5-dimethylpyrazolate quin, quinolin-8-olate solv, solvent tfb, teti afluorobenzobaiTelene THE, tetrahydrofuran THT, tetrahydrothiophene tmeda, teti amethylethylenediamine Tol, tolyl Tp, HB(C3H3N2)3 Tp , HB(3,5-Me2C3HN2)3 Tp, substituted hydrotiis(pyrazol-l-yl)borate Ts, tosyl tz, 1,2,4-triazolate Vin, vinyl. 

In a typical reaction, a series of C - O linked pyrazinone-triazoles were irradiated with an excess (3.5 equiv) of DMAD in o-DCB. The reactions were completed in 6-20 min at 180 °C, using a maximum irradiation power of 200 W. After spontaneous elimination of the corresponding isocyanate or cyanogen chloride, the pyridines and pyridinones were formed in combined yields of 71-99%. It is noteworthy that the pyrazinones with an aryl moiety at the N-1 position yielded pyridines as major products, while those with ben-zyUc or alkyl ester moieties at the N-1 position furnished the corresponding pyridinones as major products. 

The triazoles previously obtained from jS-keto-ylides and acyl azides or ethyl azidoformate are the 2-acyltriazoles (80) formed by isomerization under the basic conditions of the initially formed 1-substituted triazoles (79). The latter can be isolated in some cases if the reactions are interrupted. Aryl mono- and bis-azides have also been used in the preparation of the triazolcs (81). 

Nevertheless, the placement of two Cl atoms on the C and C carbon atoms of the NHC skeleton, the presence of the strong SO Ar electron-withdrawing group on the aryl A-substituents, or the modification of the NHC skeleton from an imidazol-to a triazol-type, have allowed to fill the gap between the TEP of phosphines and NHCs, see Pig. 1.14. 

Finally, NHC complexes of copper, formed in situ from the hnidazolium salt and CuBr have been used in the monoarylation of aniline [167]. Trinuclear Cu(I) catalysts have been applied to the arylation of pyrazoles, triazoles, amides and phenols [168] (Scheme 6.50). 

The general procedure used for the synthesis of [l,2,3]triazolo[l,2-tf][l,2,4]benzotriazin-l-5(6//)-dione derivatives 506 is shown in Scheme 86. Ionic 1,3-dipolar cycloaddition of the appropriate azide 503 to ethyl phenylacetates gives l-(2-nitrophenyl)-4-aryl-5-oxo[l,2,3]triazoles 504. Catalytic reduction of these compounds affords the corresponding amines 505. Cyclocondenzation of these amines to the final tricyclic compounds 506 is performed using triphosgene in anhydrous tetrahydrofuran solution at room temperature (Scheme 86) <2005JME2936>. 

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