1,2.3-Triazines. medicinal chemistry

Dhainaut, A., Regnier, G., Atassi, G., Pierre, A., Leonce, S., Kraus-Berthier, L. and Prost, J.F. (1992) New triazine derivatives as potent modulators of multidrug resistance. Journal of Medicinal Chemistry, 35, 2481-2496. 

The 1,2,4-substituted triazine core is a versatile scaffold to access a wide range of condensed heterocyclic ring systems via intramolecular Diels-Alder reactions with a vast array of dienophiles. The triazine ring system is also a key component of commercial dyes, herbicides, insecticides and also recently appeared in medicinal chemistry. One way to synthesise triazines is to use a three-component reaction that has been described in the literature several times, both under traditional thermal heating and under solvent-free microwave-assisted conditions42. However, the previously described methods focussed only on simple aliphatic phenyl and ester substituents. 

R.E. (2013) Discovery of 1-(1 3,5-triazin-2-yl) piperidine-4-carboxamides as inhibitors of soluble epoxide hydrolase. Bioorganic and Medicinal Chemistry Letters, 23,3584-3588. 

Ethylamine is primarily used in the production of triazine herbicides. Ethylamine has also found use in resin chemistry, oil refining, and solvent extraction as a stabilizer for latex rubber and in the manufacture of dyestuffs, medicinals, corrosion inhibitors, urethane foam catalysts, and agents used in wash-and-wear fabrics. 

Until the first half of the 20th century, 1,3,5-triazines were only of academic interest.8 9 Subsequently, successful industrial and medicinal applications have resulted in an extensive exploration of triazine chemistry, with much of the recent published information being found in the patent literature. Several reviews and monographs have been published during the last three decades,10 -21 and there are numerous reports concerning the applications of 1,3,5-triazi-nes vide infra). 

Triazine dendrimers—which are usually cationic in nature—have been largely explored as targets of synthesis and platforms for manipulation. Their application in fields including regenerative medicine will likely derive from the ability of investigators to tune molecular parameters including size, surface chemistry, and ligand density in a controlled and reproducible manner. 

Physical properties of highly branched polymers are different from their linear analogs and have many potential applications in medicine and nanoengineering. Dendritic polymers with monodispersed composition and weU-defined tree-like structures are even attractive. Efficient reactions are required, and thiol-ene was used by Hawker and coworkers to prepare dendrimers starting from a tris-alkene core 2,4,6-triallyloxy-l,3,5-triazine. 1-Thioglycerol was used to introduce two hydroxy groups via UV-irradiated thiol-ene reaction, which was carried out at room temperature for 30 min. Due to the efficient nature of thiol-ene chemistry and less byproducts, hydroxy-terminated dendrimers... 

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