Treg, T Regulatory

Autoimmune Disease. Figure 1 Mechanisms of self tolerance. DC, dendritic (antigen presenting) cell T, T-lymphocyte Th, T helper lymphocyte Treg, T regulatory lymphocyte. For details see text. 

DC, dendritic cell NK, natural killer Thl, T helper 1 Th2, T helper 2 Treg, T regulatory. 

The Th-1 /Th-2 paradigma forms a core mechanism regulating the nature of an immune response. More recently, this concept was further developed by identifying Th-subsets with predominantly suppressing properties, T-regulatory cells (Treg). These cells also play a major role in keeping those cells at rest, which have escaped central tolerance (peripheral self tolerance). 

It is established today that a set of T-regulatory cells (Tregs) as well as other T-cell subtypes are... 

Finally, there is growing evidence that besides Th2 cells, T regulatory (Treg) cells are involved in the development asthma [91, 92]. 

Tc cell cytotoxic T cell Th cell T helper cell Treg cell regulatory T cell neutro neutrophils baso basophils mono monocytes DC dendritic cells. 

Cellular therapy employing Foxp3-expressing regulatory T cells (Tregs) holds the promise to replace and/or supplement indiscriminatory... 

A variety of studies indicate that stable Foxp3 expression is sufficient to confer a regulatory T-cell phenotype to CD4 T cells [11-13]. Thus, retroviral Foxp3 transduction is a valuable means to endow antigen-specific T cells with a regulatory phenotype. This represents an important tool because, unlike the in vitro expansion [14, 15] of Tregs preformed in vivo, it allows to produce Tregs of any desired specificity. 

Regulatory T Cells Suppress DC Maturation As outlined above, several lines of evidence indicate that DCs are crucially involved in the induction of Tregs. However, this interaction is not restricted to a DC-to-Treg one-way street, since several recent data revealed that Tregs in turn have an impact on DC development [11]. 

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