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Trazodone drug administration

Major drug interactions trazodone interacts with MAOIs with the risk of serotonin syndrome. When switching between trazodone and an MAOI, a 2-week no-trazodone no-MAOI gap is necessary to safely stop and start treatment Trazodone should not be stopped abruptly. Trazodone interacts with alcohol with worsening sedation. Tegretol decreases blood levels while Nizoral and Norvir increase blood levels of trazodone. Co-administration of trazodone can increase blood concentrations of digoxin and phenytoin. Trazodone may also pass into breast milk and affect a nursing baby. [Pg.352]

SSRIs DULOXETINE, ST JOHN S WORT, SSRIs, TCAs, TRAZODONE T risk of serotonin syndrome >- For signs and symptoms of serotonin toxicity, see Clinical Features of Some Adverse Drug Interactions, Serotonin toxicity and serotonin syndrome Additive effect. In addition, TCAs inhibit CYP2D6-mediated metabolism of SSRIs Caution with co-administration with TCAs or trazodone. Specialist advice should be sought and alternatives considered. Avoid co-administration of two SSRIs, and SSRIs with duloxetine or St John s wort... [Pg.171]

See other pages where Trazodone drug administration is mentioned: [Pg.266]    [Pg.268]    [Pg.156]    [Pg.385]    [Pg.482]    [Pg.290]    [Pg.148]    [Pg.265]    [Pg.719]    [Pg.677]    [Pg.113]    [Pg.148]    [Pg.446]    [Pg.221]    [Pg.290]    [Pg.270]    [Pg.45]    [Pg.46]    [Pg.861]    [Pg.863]   


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Trazodon

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