Trapping reactive intermediate

Keywords Cellulose Trapping Reactive intermediates Reaction mechanism... 

Krebs C, Bollinger JM Jr. Freeze-quench (57,Fe-M6ssbauer spectroscopy trapping reactive intermediates. Photosynth Res. 2009 102 295-304. 

Trapping reactive intermediates by Diels-Alder reactions... 

The development of the synthesis of peptides on solid supports has also had a strong impact on other areas of organic synthesis. From the very beginning, some research groups tried, with some success, to export the idea from peptide synthesis to, for instance, the monoalkylation and monoacylation of carboxylic acids,the synthesis of aldehydes and ketones, or to the use of resin-bound dienes or dienophiles to trap reactive intermediates.PI This pioneering work has been fundamental to the much more recent explosion of combinatorial chemistry on solid supports. Synthesis on solid supports has also found application in the synthesis of oligonucleotides, PI oligosaccharides,PI peptide-DNA hybrids,P°l and peptide nucleic acids (PNAs).P l... 

Isotopically Depleted Proteins and Peptides Trapping Reactive Intermediates... 

The process for the identification of trapped reactive intermediates can be a slow, painstaking task. Strategies to screen for the occurrence of these reactive metabolites to increase the attrition of potentially toxic drugs can significantly reduce the cost of the development. Much of what follows in this chapter is focused on the development of such screening procedures. 

Trapping Reactive Intermediates from Thiophene Moiety... 

FIGURE 10.11 Proposed bioactivation pathways of thiophene-containing model compound and the schemes for trapping reactive intermediates. 

Scavenger, a compound to trap reactive intermediates. When cleaving protecting groups of the tert.-butyl or benzyl type, scavengers such as anisole, thioanisole, dimethyl sulfide, or triisopropylsilane must be added to the reaction mixture in order to avoid side reactions of the intermediate carbenium ions. 

Structural Alerts The term refers to a metabolite that belongs to a chemical class with known toxicity, a metabolite that contains positive structural alerts for certain toxicity, or a GSH adduct/mercapturic acid conjugate indicative of a trapped reactive intermediate. 

Since their conception. carcerands and hemicarcerands have been used for a number of applications including trapping reactive intermediates and studying templation processes. Examples of these applications. 

Copyright (2015) Wiley. Used with permission from Strukil V, Gracin D, Magdysyuk OV, Dinnebier RE, Frilcic T. Trapping reactive intermediates by mechanochemistry elusive ary ... 

C. Krebs, J.M. Bollinger, Freeze-quench Fe-57 Mossbauer spectroscopy trapping reactive intermediates, Photasynth. Res. 2009, 102(2-3), 295-304. 

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