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Transporters in the Gastrointestinal Tract

ABC ATP CDX CNT ENT EMT GIT GO NCE PEPT1 PMT QSAR SAR SLC ATP-binding cassette Adenosine 5 -triphosphate Caudal-type homeobox transcription factor Concentrative nucleoside transporter Equilibrative nucleoside transporter Epithelial-mesenchymal transition Gastrointestinal tract Gene ontology New chemical entity Di/tri-peptide transporter 1 Pharmacogenetics of Membrane Transporters Project Quantitative structure-activity relationship Structure-activity relationship Solute carriers (SLCs) [Pg.223]

Active Transport Along the Intestine and Influence on Drug Absorption [Pg.228]

Transporter family Transporter0 Source1 Expression Source0 SNP Xenobiotic substrates11 [Pg.229]

SLC15A SLC15A/PEPT1 Small intestine, all three segments [3, 4] [61, 62] (5-Lactam antibiotics (e.g., cephalexin), various amino acid and dipeptide prodrugs (e.g., valaddovir) [2, 8-10] [Pg.229]

SLC28A SLC28A1/CNT1 Small intestine, all three segments [3, 4] [64] Azidothymidine, cemcitabine [20-22] [Pg.229]


S Suzuki, WI Higuchi, NFH Ho. Theoretical model studies of drug absorption and transport in the gastrointestinal tract. I. J Pharm Sci 59 644-651, 1970. [Pg.419]

Suzuki A, Higuchi WI and Ho NF (1970a) Theoretical Model Studies of Drug Absorption and Transport in the Gastrointestinal Tract. I. J Pharm Sc. 59 pp 644-651. [Pg.69]

Schweigel M and Martens H (2000) Magnesium transport in the gastrointestinal tract. Front Biosd 5 D666-D677. [Pg.597]


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Gastrointestinal tract

The gastrointestinal tract

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