Transmembrane drugs

Zaman GJ, Versantvoort CH, Smit JJ, et al. Analysis of the expression of MRP, the gene for a new putative transmembrane drug transporter, in human multidrug resistant lung cancer cell lines. Cancer Res 1993 53 1747-1750. 

L., Venkatesh Pratap, J., Bavro, V.N., Miguel, R.N., Mizuguchi, K., and Luisi, B. (2004) A model of a transmembrane drug-efflux pump from Gram-negative bacteria. FEBS Letters, 578 (1-2), 5-9. 

Antiarrhythmic Drugs. Figure 1 Transmembrane ionic currents of the cardiac action potential. In the middle of the figure, a typical cardiac action potential is shown as can be obtained from the ventricular myocardium (upper trace). Below, the contribution of the various transmembrane currents is indicated. Currents below the zeroline are inward currents above the zero line are outward fluxes. In the left column the name of the current is given and in the right column the possible clone redrawn and modified after [5]. 

Drug Interactions Drug-Receptor Interaction G-protein-coupled Receptors Tolerance and Desensitization Transmembrane Signaling... 

DHP drugs bind allosterically. The open L-channel is somehat more permeable to the Ba ion than to the Ca ion but is very much less permeable to the Na ion. Nonetheless, because Na ion concentrations are so much higher than Ca ion concentrations, the actual fraction of charge carried by the two ions is not always so clear. There are a number of states that the L-channel can be in, aside from simply being open or closed. It is the distribution of L-channel molecules among the various states that is influenced by transmembrane voltage. From another view the rate constants between the states are functions of the transmembrane voltage. 

Reeves ID, McKnight A, Potempa S et al (1997) CD4-independent infection by HlV-2 (ROD/B) use of the 7-transmembrane receptors CXCR-4, CCR-3, and V28 for entry. Virology 231 130-134 Ribeiro JA (2005) What can adenosine neuromodulation do for neuroprotection Curr Drug Targets CNS Neurol Disord 4 325-329... 

Except for its narrow specificity, the ATRI gene product shares a number of properties with the higher eukaryotic MDR proteins responsible for multidrug resistance in tumour cells. The MDR gene products are also transmembrane proteins which seem to function as ATP-dependent drug-efflux pumps pumping out a variety of structurally unrelated compounds (see [25,26]). 

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