Translocation of HSL

Recently, the involvement of multiple mechanisms for hormonal regulation of lipolysis by HSL has convincingly been demonstrated with transgenic mice expressing human HSL in WAT [258]. HSL mRNA levels were increased in WAT by 

---

Fig. 11.4 Hypothetical model for integration of the major mechanisms of TAG storage and mobilization (1) conversion of fibroblasts/ preadipocytes into adipocytes, (2) biogenesis of forming LD at the ER membrane, (3) fusion of smaller LD to mature LD, (4) translocation of HSL from the cytosol to the surface of LD, (5) disassembly and reorganization at...

Fig. 11.6 (Hormonal) regulation of TAG mobilization in adipocytes by translocation of HSL and perilipin as well as the molecular mechanisms involved (phosphorylation by PKA, dephosphorylation by protein phospha-...

Inhibition of the translocation of HSL from the cytosol to LD, for instance, by upregulation of perilipin expression or blockade of PKA-dependent phosphorylation of HSL and perilipin, or enhancement of the HSL-lipotransin interaction during inhibition of the lipotransin ATPase. 

---