Transition-metal-free synthesis

Yonker, C. R. and Linehan, J. C., A high-pressure NMR investigation of reaction chemistries in a simple salt hydrate,. Supercrit. Fluids, 29, 257 2004. Mehnert, C. R, Supported ionic liquid catalysis, Chem. Eur. ]., 11,50,2005. Giernoth, R. and Bankmann, D., Transition-metal free synthesis of perdeuter-ated imidazolium ionic liquidsby alkylation and H/D exchange, Eur. J. Org. Chem., 2008 (in print). DOT 10.1002/ejoc.200700784. 

Multiple more environmentally safe protocols were reported in 2013. The Karade group described a facile, mild, transition-metal-free synthesis... 

Wang Y, Watson MD (2006) Transition-metal-free synthesis of alternating thiophene-perfluoroarene copolymers. J Am Chem Soc 128 2536—2537... 

Transition-Metal Free Synthesis of BenzO Fused Five- and Six-Membered Heterocycles Employing Arynes... 

TRANSITION-METAL-FREE SYNTHESIS OE BENZO-FUSED FIVE- AND SIX-MEMBERED HETEROCYCLES EMPLOYING ARYNES... 

The transition metal-free synthesis of A-acyl diarylamines has been achieved through a three-step process (Scheme 3.62) [68]. Although many steps were involved in this approach, moderate to good yields of the desired compounds were obtained for most substrates. 

SCHEME 4.367 Transition metal-free synthesis of alkynylphosphonates in open vessels [541]. 

The transition metal-free synthesis of alkynylphosphine oxides can be accomplished using iodonium salts. Can this chemistry be extended to alkynylphosphonates ... 

SCHEME 5.38 Transition metal-free synthesis of unsymmetrical diaryl sulfides [60]. 

SCHEME 5.48 Transition metal-free synthesis of diaryl sulfones [70],... 

The transition metal-free synthesis of an alkylboronate has been achieved using a PhMCjSi-Bpin as the borylating agent and an alkyl bromide as the substrate (Scheme 6.3) [3]. One of the issues with this chemistry was a competing silylation reaction, which... 

Need a transition metal-free synthesis of an arylboronic acid... 

A clever transition metal-free synthesis of Z-vinylboronates was reported by Molander (Scheme 6.43) [83]. Instead of focusing on trying to devise a ligand architecture for a... 

Wang W, Zhao X-M, Wang J-L, Geng X, Gong J-F, Hao X-Q, Song M-P (2014) Transition metal-free synthesis of primary amides from aldehydes and hydroxylamine hydrochloride. Tetrahedron Lett 55(20) 3192-3194... 

Han X, Zhang Y, Wu J. Mild two-step process for the transition-metal-free synthesis of carbon-carbon bonds from allylic alcohols/ethers and Grignard reagents. J. Am. Chem. Soc. 2010 132 4104-4106. 

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