Transition metal complexes, genetic

For all these reasons, some chemical or genetical modifications have been applied into the binding sites of antibodies in order to improve their reactivity [22]. Antibodies can be modified by the incorporation of natural or synthetic catalysts into the antibody recognition site, as for instance transition metal complexes, cofactors, and bases or nucleophiles, to carry other catalytic functions, which open the way to... 

The Genetic Toxicology of Substitutionally Inert Transition Metal Complexes... 

Figure 1. Examples of various modes of interaction in the universal coordination entity a) covalent bonds in a transition metal complex b) ion dipole bonding in an alkali metal complex c) hydrogen bonding in an ammonium ion receptor, d) x-stacking and hydrogen bonding in a genetic base receptor.

Figure 3 Schematic illustration of a hybrid hydrogel system—genetically engineered coiled-coil protein domains used to crosslink synthetic water-soluble polymers. Divalent transition metal ions are shown to form complexes with nitrogen-oxygen-donor ligands on the synthetic polymer side chains and the terminal histidine residues in the coiled coils.

The first transition metal catalysis using BINAP-ruthenium complex in homogeneous phase for enantioselective hydrogenation of P-ketoesters was developed by Noyori and co-workers [31]. Genet and co-workers described a general synthesis of chiral diphosphine ruthenium(II) catalysts from commercially available (COD)Ru(2-methylallyl)2 [32]. These complexes preformed or prepared in situ have been found to be very efficient homogeneous catalysts for asymmetric hydrogenation of various substrates such as P-ketoesters at atmospheric pressure and at room temperature [33]. 

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