Transformed cells sialoglycoproteins

Most cells in culture have a substantial amount of sialic acid, the bulk of which is associated with glycoproteins (Weinstein et al., 1970) and is primarily localized on the cell surface (Click et aL, 1971), cf. Chapter 3. Because the plasma membrane of cells is of prime interest in the transformation process, considerable research has been directed towards investigating changes in sialic acid and sialoglycoproteins after transformation. 

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