Transduction functions

FIGURE 3.5 Major components of classical receptor theory. Stimulus is the product of intrinsic efficacy (s), receptor number [R], and fractional occupancy as given by the Langmuir adsorption isotherm. A stimulus-response transduction function f translates this stimulus into tissue response. The curves defining receptor occupancy and response are translocated from each other by the stimulus-response function and intrinsic efficacy. 

The Furchgott method can be effectively utilized by fitting the dose-response curves themselves to the operational model with fitted values of x (before and after alkylation) and a constant KA value. When fitting experimental data, the slopes of the dose-response curves may not be unity. This is a relevant factor in the operational model since the stimulus-transduction function of cells is an integral part of the modeling of responses. Under these circumstances, the data is fit to (see Section 3.13.3 and Equation 3.49)... 

The output signal from a sensor depends on the transduction function (91/). It is related to the occupancy of the binding sites by... 

Mato, S., Del Olmo, E., and Pazos, A. (2003). Ontogenetic development of cannabinoid receptor expression and signal transduction functionality in the human brain. Eur. J. Neurosci. 17, 1747-1754. 

P. Veng-Pedersen and N. B. Modi, Pharmacodynamic system analysis of the biophase level predictor and the transduction function. J Pharm Sci 81 925-934 (1992). 

What signal-transduction functions do SH2 domains in proteins serve ... 

If the transduction function, N( ), is monotonic, which is often the case, then an inverse function exists, /V ( )> which when applied to the model results in a transformed effect, that is linearly related to the drug input through a convolution ... 

Thus, if the transduction function (and thus its inverse) can be determined in addition to the UIR, then it is subsequently possible to do deconvolution based on effect vs. time data. ... 

Polydiacetylene-based conjugated vesicles (PDA vesicles) with alternating ene-yne backbone structures constitute self-assembled nanostructures that produce blue-to-red transitions (Figure 16.8a) under the influence of molecular recognition or surface perturbations. Such self-assembled nanostructures efficiently integrate molecular recognition and signal transduction functions. 

Lipid raft A membrane area enriched in cholesterol and sphingolipids, also referred to as membrane microdomains or sphingolipid microdomains. Lipid rafts are involved in signal transduction functions. Most brain pathogens use lipid raft as portal of entry in brain cells. 

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