Transcription factors genetics

General Anaesthetics General Transcription Factors Genetic Polymorphism... 

George H, Terracol R 1997 The vrille gene of Drosophila is a maternal enhancer of decapentaplegic and encodes a new member of the bZIP family of transcription factors. Genetics 146 ... 

The subsequent articles take up such matters as origins, genetic testing for risk, detection by nucleic-based acid methods, oncogene transcription factors, genetic approaches in the discovery of anticancer drags, environment and cancer, and chrano-prevention. 

The genetic basis of at least some aspects of the proliferation response has recently been uncovered. Work with Arahidopsis mutants has shown that a nitrate-inducible gene (ANRI) encodes a member of the MADS box family of transcription factors (87). Repression of this gene resulted in plants that no longer responded to nitrate-rich patches. 

Fig. 3.13. A simplified version of a genetic construct which requires not only a reading frame to generate the m-RNA and then the protein but requires a binding region for the polymerase machinery and an instruction region for the binding of a transcription factor, both of which must be bound in appropriate form before reading can occur. The form of the transcription factor which may interact by feedback with an element, M, can be adjusted (by [M]) to stop reading. The whole is necessary for cell operations not just for that of DNA reactions.

In some ways it is surprising that aerobic bacteria have not made more use of zinc, internally, and calcium generally, especially in controls since we know they present no redox threat and we shall see that their uses increase dramatically in eukaryotes. The aerobic bacteria do have genetic connections for controlling zinc (e.g. the transcription factor ZUR and ZntR genes) but its use is not extensive. The absence of full use of Ca and Zn may well be due to the limited space and the fast time of the bacterial cell metabolism and life cycle. 

Immink, R. G., Ferrario, S., Busscher-Lange, J., Kooiker, M., Busscher, M. and Angenent, G. C. (2003). Analysis of the petunia MADS-box transcription factor family. Mol. Genet. Genomics 268, 598-606. 

---