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Transcription factor pathways

Yuan PX, Manji HK. Lithium Stimulates Gene Expression Through the AP-1 Transcription Factor Pathway. Mol Brain Res 1998 58 225-230. [Pg.414]

Cheng X, Maher J, Dieter MZ, et al. Regulation of mouse organic anion-transporting polypeptides (Oatps) in liver by prototypical microsomal enzyme inducers that activate distinct transcription factor pathways. Drug Metab Dispos 2005 33 1276-1282. [Pg.203]

Another study by Potter et al. looked at genotypes in the TLR (toll-like receptor) and NFkB (nuclear factor kappa B, a transcription factor) pathways to predict response to anti-TNF therapy in RA. A total of 187 SNPs in these pathways were studied in 909 patients with RA. Twelve SNPs in nine genes showed a nominal association with treatment response in patients on anti-TNF therapy [122],... [Pg.648]

Interference with other transcription factor pathways... [Pg.896]

In humans, the enzyme that puts oxygen onto collagen fibers. .. C. Loenarz et al. The hypoxia-inducible transcription factor pathway regulates oxygen sensing in the... [Pg.302]

D.J. McCulley, B.L. Black, Transcription factor pathways and congenital heart disease, Curr Top Dev Biol 100 (2012) 253-277,... [Pg.101]

In addition to those described above, some of the newest compounds emerging in SERM development are ER 3-selective ligands and pathway-selective modulators that target the interaction of the ERs with the transcription factor NFkB. While such compounds are in the early stages of clinical evaluation, thus far they demonstrate great potential for use in the treatment of inflammatory disorders such as arthritis, inflammatory bowel disease, and like other SERMs, cancer [4]. [Pg.1116]

TAK-1 can also activate c-jun N-terminal kinase ( JNK) andp38 both of which are MAP kinases. JNK activates the transcription factor AP-1 and p38 is involved in mRNA stabilisation. This pathway is also capable of activating ERF-7 in dendritic cells in response to TLR-7 and TLR-9 ligands. [Pg.1209]

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See also in sourсe #XX -- [ Pg.22 ]



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