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Transcript integrity

DNA Damage and Transcription Elongation Consequences and RNA Integrity Table 17.2 DNA lesions effect on transcript integrity. [Pg.424]

The transcriptional activity of NRs is also modulated by various posttranslational modifications of the receptors themselves or of their coregulatory proteins. Phosphorylation, as well as several other types of modification, such as acetylation, SUMOylation, ubiquitinylation, and methylation, has been reported to modulate the functions of NRs, potentially constituting an important cellular integration mechanism. In addition to the modifications of the receptors themselves, such modifications have been reported for their coactivators and corepressors. Therefore, these different modes of regulation reveal an unexpected complexity of the dynamics of NR-mediated transcription. [Pg.898]

A nuclear receptor that is a key transcription factor in adipocytes. It plays a critical role in the control of adipocyte differentiation and is involved in the regulation of the expression of specific adipokines, including leptin and adiponectin. It has anti-inflammatory actions and is the target of the thiazolidinedione drugs. The preintegration complex is a complex of retroviral DNA and proteins that translocates from the cytosol into the nucleus prior to integration. Gene Therapy... [Pg.998]

See other pages where Transcript integrity is mentioned: [Pg.8]    [Pg.97]    [Pg.262]    [Pg.266]    [Pg.428]    [Pg.374]    [Pg.78]    [Pg.104]    [Pg.400]    [Pg.407]    [Pg.409]    [Pg.341]    [Pg.32]    [Pg.8]    [Pg.97]    [Pg.262]    [Pg.266]    [Pg.428]    [Pg.374]    [Pg.78]    [Pg.104]    [Pg.400]    [Pg.407]    [Pg.409]    [Pg.341]    [Pg.32]    [Pg.36]    [Pg.129]    [Pg.175]    [Pg.192]    [Pg.30]    [Pg.158]    [Pg.186]    [Pg.199]    [Pg.531]    [Pg.637]    [Pg.639]    [Pg.711]    [Pg.894]    [Pg.899]    [Pg.941]    [Pg.1224]    [Pg.1225]    [Pg.1229]    [Pg.1284]    [Pg.1285]    [Pg.36]    [Pg.428]    [Pg.302]    [Pg.140]    [Pg.11]    [Pg.29]    [Pg.168]    [Pg.140]    [Pg.147]    [Pg.308]    [Pg.325]    [Pg.379]    [Pg.386]   
See also in sourсe #XX -- [ Pg.424 ]



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