Transbronchial lung biopsy

Dodson RF, Hurst GA, Williams MG, et al. 1988. Comparison of light and electron microscopy for defining occupational asbestos exposure in transbronchial lung biopsies. Chest 94 366-370. 

A 35-year-old woman with ulcerative colitis who had taken mesalazine 1.5 g/day for about 40 days developed a low-grade fever with bilateral eosinophUic pulmonary infUtrates (confirmed by transbronchial lung biopsy)... 

A 53-year-old Japanese man, who had taken skullcap intermittently for hemorrhoids, developed recurrent interstitial pneumonitis (17). Re-challenge, after he had stopped taking the herbal remedy and had become symptom free, resulted in a high fever and signs and symptoms of interstitial pneumonitis. Transbronchial lung biopsy showed Ijmphocytic alveolitis with eosinophilic infiltration. The symptoms subsided again after withdrawal. 

Takamura K, Nasuhara Y, Mishina T, et al. Intravascular lymphomatosis diagnosed by transbronchial lung biopsy. Eur Respir J. 1997 10 955-957. 

Respiratory Three cases of interstitial pneumonia have been described in Japanese patients during treatment with bepridil. In one case, exertional dyspnea developed over 8 months and transbronchial lung biopsy specimens showed moderate lymphocytic infiltration glucocorticoid therapy led to resolution in 3 weeks [48 ]. The other two patients developed pneumonia after 20 and 60 days one required glucocorticoid treatment and the other was discharged having improved after bepridil withdrawal [49 ]. 

Gilman MJ, Wang KP. Transbronchial lung biopsy in sarcoidosis an approach to determine the optimal number of biopsies. Am Rev Respir Dis 1980 122 721. 

Ohara K, Okubo A, Kamata K, et al. Transbronchial lung biopsy in the diagnosis of suspected ocular sarcoidosis. Arch Ophthalmol 1993 111 642-644. 

Surgically obtained lung biopsy is required to confirm the diagnosis. Transbronchial lung biopsy has a limited role as a confirmatory procedure and is mainly used to exclude infectious processes. 

A 32-year-old male was investigated for a persistent parenchymal lung abnormality. Transbronchial lung biopsy was performed. Severe bleeding began immediately after the third biopsy. Adrenaline (5mL, 1 20,000) was instilled via the guide sheath. Within seconds, VF developed. Restoration of sinus rhythm was achieved by direct cardioversion (250]). 

A Caucasian female was diagnosed with bronchiolitis obliterans organising pneumonia (BOOP)-like interstitial pneumonia (transbronchial lung biopsy) after 9 months of PTU therapy for amiodarone-induced TTX (thyroidihs without nodules). Values for antinuclear antibody (ANA) and ANCA were negative and tiie BOOP-like interstitial pneumonia was resolved after discontinuation of PTU. 

Chamberlain D, Maurer J, Chaparro C, Idolor L (1994) Evaluation of transbronchial lung biopsy specimens in the diagnosis of bronch iolit is obliterans after lung transplantation. J Heart Lung Transplant 13 963-971... 

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