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Transaldolase, reaction catalyzed

Transaldolase, which catalyzes reactions with d-erythrose 4-phosphate and D-fructose 6-phosphate as substrates. As in the case of fructose-1,6-bisphosphate aldolase, this enzyme uses a e-amino side-chain to form a Schiff base intermediate. In this case, however, the triose phosphate moiety is not released but is transferred to the other aldose (in this case, the aldotetrose). [Pg.46]

FIGURE 20-10 Third stage of C02 assimilation. This schematic diagram shows the interconversions of triose phosphates and pentose phosphates. Black dots represent the number of carbons in each compound. The starting materials are glyceraldehyde 3-phosphate and dihydroxyacetone phosphate. Reactions catalyzed by transaldolase ( and ) and transketolase ((3) and ) produce pentose phosphates that are converted to ribulose 1,5-bisphosphate—ribose... [Pg.759]

Transaldolase catalyzes a two-step conversion. The first step, an aldol cleavage of the bond between C-3 and C-4 of a ketose, is essentially identical to the reaction catalyzed by aldolase. However, the dihydroxyacetone that is produced in the transaldolase reaction from carbons 1, 2, and 3 is not released. Rather, it is held at the catalytic site while the glyceraldehyde-3-phosphate produced diffuses away and is replaced by erythrose-4-phosphate. An aldol condensation then generates the second product of the reaction, a ketose that contains the first three carbon atoms of the original ketose attached to C-1 of the acceptor aldose (fig. 12.32). [Pg.273]

The reaction catalyzed by transketolase superficially resembles the transaldolase reaction in that the substrate... [Pg.273]

The transketolase and transaldolase reactions are reversible and so allow either the conversion of ribose 5-phosphate into glycolytic intermediates when it is not needed for other cellular reactions, or the generation of ribose 5-phosphate from glycolytic intermediates when more is required. The rate of the pentose phosphate pathway is controlled by NADP+ regulation of the first step, catalyzed by glucose 6-phosphate dehydrogenase. [Pg.298]

Enzymatic Reaction Mechanisms II Biochemical reactions often look more complex than they really are. In the pentose phosphate pathway (Chapter 14), sedoheptulose 7-phosphate and glycer-aldehyde 3-phosphate react to form erythrose 4-phosphate and fructose 6-phosphate in a reaction catalyzed by transaldolase. [Pg.139]

Understand the physiologic importance of the hexose monophosphate shunt and understand reactions catalyzed by glu-cose-6-phosphate and 6-phosphogluconate dehydrogenases, transaldolase, and transketolase discuss the importance of the hexose monophosphate shunt in red cell physiology. [Pg.461]

The reactions catalyzed by transketolase and transaldolase are distinct yet similar in many ways. One difference is that transketolase transfers a two-carbon unit, whereas transaldolase transfers a three-carbon unit. Each of these units is transiently attached to the enzyme in the course of the reaction. In transketolase, the site of addition of the unit is the... [Pg.845]

E. In the first three reactions of the pentose phosphate pathway, glucose is converted to ribulose 5-phosphate and C02, with the production of NADPH. These reactions are not reversible. Ribose 5-phosphate and xylulose 5-phosphate may be formed from ribulose 5-phos-phate. A series of reactions catalyzed by transketolase and transaldolase produce the glycolytic intermediates fructose 6-phosphate and glyceraldehyde 3-phosphate. [Pg.182]

The reactions catalyzed by the epimerase, isomerase, transketolase, and transaldolase are all reversible reactions under physiologic conditions. Thus, ribose 5-phosphate required for purine and pyrimidine synthesis can be generated from intermediates of the glycolytic pathway, as well as from the oxidative phase of the pentose phosphate pathway. The sequence of reactions that generate ribose 5-phos-phate from intermediates of glycolysis is indicated below. [Pg.536]

In the reaction catalyzed by transaldolase, a three-carbon unit is transferred from the seven-carbon sedoheptulose-7-phosphate to the three-carbon glyceraldehyde-3-phosphate (Figure 18.15, red numeral 2). The products of the reaction are fructose-6-phosphate (six carbons) and erythrose-4-phos-phate (four carbons). [Pg.538]

As we have seen, the reactions catalyzed by transketolase and transaldolase are reversible, which allows the pentose phosphate pathway to respond to the needs... [Pg.538]

As shown in Figure 12-2, the 7-carbon sugar, sedoheptulose-7-phosphate, and the 3-carbon sugar, glyceraldehyde-3-phosphate, react again, in a reaction catalyzed by transaldolase (3-carbon transfer) ... [Pg.168]

Explain how the pentose phosphate pathway and the glycolytic pathway are linked through reactions catalyzed by transaldolase and transketolase. [Pg.347]

The Transketolase-Transaldolase Pathway. The second, non-oxidative, mechanism involves a series of transfer reactions catalyzed by the enzymes transketolase and transaldolase. [Pg.25]

Transfer of dihydroxyacetone moiety from sedoheptulose 7-phosphate onto glyceraldehyde 3-phosphate. This reaction is reversible and is catalyzed by transaldolase according to the scheme ... [Pg.182]

I, 7-diphosphate.170 1 (f> This tetrose phosphate is involved with phosphoenol pyruvate in the formation of shikimic acid via 3-deoxy-2-keto-D-ara6ino-heptonic acid 7-phosphate and, hence, of aromatic compounds.170(d) A synthesis of the tetrose phosphate has been described.170 1 Aldolase shows a high affinity for the heptulose diphosphate and, compared with that for D-fructose 1,6-diphosphate, the rate of reaction is about 60 %. The enzyme transaldolase, purified 400-fold from yeast, catalyzes the following reversible reaction by transfer of the dihydroxyacetonyl group.l70(o>... [Pg.218]

In the second phase, transaldolase (with TPP as cofactor) and transketolase catalyze the interconversion of three-, four-, five-, six-, and seven-carbon sugars, with the reversible conversion of six pentose phosphates to five hexose phosphates. In the carbon-assimilating reactions of photosynthesis, the same enzymes catalyze the reverse process, called the reductive pentose phosphate pathway conversion of five hexose phosphates to six pentose phosphates. [Pg.555]

The transaldolase-catalyzed conversion of fructose-6-phosphate and erythrose-4-phosphate to glyceraldehyde-3-phosphate and sedoheptulose-7-phosphate. This is a two-step conversion. The first step is similar to the aldolase reaction except that the dihydroxyacetone produced is held at the catalytic site while the aldose product diffuses away and is replaced by another aldose molecule. The second step involves an aldol condensation. [Pg.273]

Transketolases are characterized by their ability to transfer a two-carbon unit from a ketose to an aldehyde. The C3 and C7 sugar-phosphates can subsequently be converted to a C4 and a Csugar-phosphate, erythrose 4-phosphate (3.17) and fructose 6-phosphate (3.2), respectively. This reaction is catalyzed by a transaldolase, which transfers a three-carbon glyceraldehyde unit from an aldose to a ketose. Erythrose-4-phosphate (3.17) can be used in the shikimate pathway (see Section 6). A second transketolase reaction can generate a second fructose-6-phosphate (3.2) and glyceraldehyde-3-phosphate (3.4) residue from erythrose-4-phosphate (3.17) and xylulose-5-phosphate (3.15). Hexose-phosphate isomerase converts the... [Pg.79]

The preceding reactions yield two molecules of NADPH and one molecule of ribose 5-phosphate for each molecule of glucose 6-phosphate oxidized. However, many cells need NADPH for reductive biosyntheses much more than they need ribose 5-phosphate for incorporation into nucleotides and nucleic acids. In these cases, ribose 5-phosphate is converted into glyceraldehyde 3-phosphate and fructose 6-phosphate by transketolase and transaldolase. These enzymes create a reversible link between the pentose phosphate pathway and glycolysis by catalyzing these three successive reactions. [Pg.844]

Transaldolase catalyzes the transfer of a C3 unit. The reaction occurs via an aldol cleavage similar to that seen with aldolase there is a schiff base intermediate formed with an active site lysine. The difference between aldolase and transaldolase is in the acceptor groups in aldolase the acceptor is a proton, in transaldolase it is another sugar. This reaction yields a F-6-P, which can go to Glycolysis, and an E-4-P which reacts with Xu-5-P catalyzed by the same transketolase seen above. This second transketolase reaction yields F-6-P and Ga-3-P, both intermediates of Glycolysis and the end products of the Pentose-P pathway. [Pg.311]

Transferases Catalyze the group transfer reactions Glycosyltransferases, transketolases, methyltransferases, transaldolases, acyltransferases, transaminases... [Pg.105]


See other pages where Transaldolase, reaction catalyzed is mentioned: [Pg.766]    [Pg.12]    [Pg.93]    [Pg.553]    [Pg.145]    [Pg.298]    [Pg.227]    [Pg.247]    [Pg.167]    [Pg.262]    [Pg.309]    [Pg.360]    [Pg.553]    [Pg.539]    [Pg.122]    [Pg.49]    [Pg.251]    [Pg.552]    [Pg.760]    [Pg.277]    [Pg.226]    [Pg.479]    [Pg.270]    [Pg.295]    [Pg.1418]   
See also in sourсe #XX -- [ Pg.273 , Pg.273 ]




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Transaldolase

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