Tranquilizers fluphenazine

The principle of making depot preparations by esterification is widely applied not only to steroid hormones, but also to other drugs (e.g vitamin K, the tranquillizer fluphenazine, and the antimalarial amodiaquine (Fig. 35)158,159> and in the field of pesticides to the weedkiller dichlorophenoxyacetic acid. 

In the 1960s, potent major tranquilizers such as haloperidol (Haldol) and fluphenazine (Prolixin) were new on the psychiatric scene. Many of these synthetic butyrophenones were sufficiently potent to warrant at least preliminary testing in our program. Fluphenazine and 302034 (haloperidol) both impaired NF performance... 

OFFICIAL NAMES Major tranquilizers (neuroleptics/antipsychotics) Chlorpromazine (Thorazine) chlorprothixene (Taractan) clozaril (Clozapine) fluphenazine (Permitil, Prolixin) haloperidol (Haldol) loxapine (Daxolin, Loxitane) mesoridazine (Serentil) molindone (Lidone,... 

I iorinal see Barbiturates Rower of paradise see Catha edulis Rumethiazide see Diuretics Runitrazepam see Rohypnol Ruoxetine Prozac see Antidepressants Fluphenazine see Tranquilizers Flurazepam see Benzodiazepine Footballs see Amphetamines Forget-me pill see Rohypnol... 

Clinically important, potentially hazardous interactions with alcohol, anticholinergics, barbiturates, benzodiazepines, butabarbital, chloral hydrate, chlordiazepoxide, chlorpromazine, clonazepam, clorazepate, diazepam, ethchlorvynol, fluphenazine, flurazepam, hypnotics, lorazepam, MAO inhibitors, mephobarbital, mesoridazine, midazolam, narcotics, oxazepam, pentobarbital, phenobarbital, phenothiazines, phenylbutazone, primidone, prochlorperazine, promethazine, quazepam, secobarbital, sedatives, temazepam, thioridazine, tranquilizers, trifluoperazine, zolpidem... 

Electrophoresis was carried out on fluphenazine hydrochloride and several other phenothiazine tranquilizers in various buffers proposed by Werrum. A Gordon-Misco apparatus, Whatman 3MM paper 30 cm in width, and a potential difference of 500 to 800 v were used. Detection of spots was carried out with a 40% sulfuric acid... 

Gas-Liquid Chromatographic Analysis Fluphenazine was not eluted after 90 minutes at 270°, using a 210 SE-30 silicone polymer on a 80-100 mesh Gas-chrom S diatomaceous earth column with a 3% SE-30 on 80-100 mesh Gas-chrom Q at 250°C, it eluted in 4.9 minutes. Fluphenazine was also well separated from other tranquilizers on a 120 mesh silanized Gas-chrom P column coated with 1% Hi-Eff-8B (cyclohexane-dimethanol succinate) at a temperature of 220°C and a retention time of 5 minutes. The identification of fluphenazine and other phenothiazine tranquilizers by gas chromatography of their pyrolysis products has also been reported. 

The neuroleptic (at first called tranquillizing ) action of these pheno-thiazines was later found in other chemical series, notably among the thioxan-thenes [e.g. chlorprothixene 12.111)]. and butyrophenones [e.g. haloperidol 12.112)]. At first, the dose of the butyrophenones was much lower than was needed for the other two categories, but now these too have low-dose examples such as perphenazine, trifluoperazine, fluphenazine, and thiothixene. ... 

Figure 4.19 The stabilizing and lytic effects of various tranquilizers and antihistamines on human erythrocytes. Stabilization of the erythrocytes against hypotonic haemolysis is caused by butyrylperazine dimaleate, prochlorperazine ethane disulphonate, fluphenazine diHCl, reserpine phosphate, thioridazine HCl, trifluoperazine diHCl, chlorpromazine HCl, promethazine HCl, and haloperidol. High concentrations of all the compounds caused direct lysis. Stabilization by chlorpromazine sulphoxide occurred at concentrations higher than equiosmolar concentrations of NaCl or sucrose. All the compounds were dissolved in aqueous solution except haloperidol which was added to the final aqueous solution from concentrated stock ethanolic solutions. The final concentration of the erythrocytes was 2.4 x 10 cells ml A relative haemolysis of 1.0 indicates an absolute degree of haemolysis of around 40%. From Seeman and Weinstein [158] with permission.

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