Tramadol Foods

Clinically important, potentially hazardous interactions with amitriptyline, amoxapine, amphetamines, bupropion, citalopram, clomipramine, cyproheptadine, desipramine, dextroamphetamine, dextromethorphan, diethylpropion, dopamine, doxepin, entacapone, ephedrine, epinephrine, fluoxetine, fluvoxamine, imipramine, levodopa, mazindol, meperidine, methamphetamine, nefazodone, nortriptyline, paroxetine, phendimetrazine, phentermine, phenylephrine, phenylpropanolamine, pizotifen, protriptyline, pseudoephedrine, rizatriptan, sertraline, sibutramine, sumatriptan, sympathomimetics, tramadol, tricyclic antidepressants, trimipramine, tryptophan, tyramine-containing foods, venlafaxine, zolmitriptan... 

Food can delay the absorption of dextropropoxyphene (propoxyphene), but the total amount absorbed may be slightly increased. Food increases the bioavailability of oral morphine solution and produces a sustained serum level, however, the absorption of some controlled-release preparations of morphine may be delayed by food. Food may also increase the bioavailability of oxycodone solution, but sustained-release preparations of oxycodone and tramadol and immediate-release hydromorphone appear not to be affected by food. 

In an open, crossover study in 24 healthy subjects, tramadol sustained-release capsules were found to be bioequivalent with and without concurrent food intake (high-fat breakfast). ... 

According to the manufacturer s prescribing information, the initial recommended dosage of tramadol ER is 100 mg once daily, with titration in 100 mg increments every 5 days (if required) up to a maximum dosage of 300 mg once daily. The drug is to be used in adults only, and may be administered without regard to food. 

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