TRAIL Tumor necrosis factor-related

HBV, hepatitis B HCV, hepatitis C IAP, inhibitor of apoptosis protein DBM, IAP binding motifs INCA, inhibitory CARD NASH, non-alcoholic steatohepatitis PCD, programmed cell death PCI, pan-caspase inhibitor OA, osteoarthritis RA, rheumatoid arthritis Smac, second mitochondria-derived activator of caspases TRAIL, tumor necrosis factor-related apoptosis-inducing ligand. 

TRAIL tumor necrosis factor related apoptosis inducing ligand... 

European researchers found recently that retinoic acid-induced apoptosis in leukemia cells was mediated by paracrine action of tumor-selective death ligand trail (tumor necrosis factor-related apoptosis-inducing ligand) [4]. 

Griffith, T.S. et al., Monocyte-mediated tumoricidal activity via the tumor necrosis factor-related cytokine, TRAIL, J Exp Med, 189, 1343, 1999. 

Jung EM, Lim JH, Lee TJ, Park JW, Choi KS, Kwon TK. 2005. Curcumin sensitizes tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis through reactive oxygen species-mediated upregulation of death receptor 5 (DR5). 

In hematopoietic cehs, cytokines also regulate death receptor-mediated pathways. Hematopoietic cytokines, such as IL-3 and erythropoietin in normal cells and BCR-ABL oncoprotein in transformed cells, inhibit transcription of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL). The inhibition of TRAIL function is sufficient to partially rescue cytokine-deprived cells from apoptosis. Cytokine and BCR-ABL suppression of TRAIL transcription is mediated through phosphorylation and inhibition of the forkhead F0X03a transcription factor. BCR-ABL-induced inhibition of TRAIL transcription in hematopoietic cells may provide a novel mechanism for tumorigenicity in chronic myeloid leukemia. ... 

Miura Y, Misawa N, Maeda N, Inagaki Y, Tanaka Y, Ito M et al. Critical contribution of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) to apoptosis of human CD4+ T cells in HIV-1-infected hu-PBL-NOD-SCID mice. The journal of experimental medicine 2001 193(5) 651-660... 

Smyth MJ, Cretney E, Takeda K, Wiltrout RH, Sedger LM, Kayagaki N, Yagita H, Okumura K (2001a) Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) contributes to interferon gamma-dependent natural killer cell protection from tumor metastasis. J Exp Med 193 661-670... 

Jazirehi, A.R., Ng, C.P., Gan, X.H., Schiller, G., and Bonavida, B. (2001). Adriamycin sensitizes the adriamycin-resistant 8226/Dox40 human multiple myeloma cells to Apo2I-/tumor necrosis factor-related apoptosis-inducing ligand-mediated (TRAIL) apoptosis. Clin. Cancer Res. 7, 3874-3883. 

Schempp, C.M., Simon-Haarhaus, B., Termeer, C.C., and Simon, J.C., Hypericin photo-induced apoptosis involves the tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and activation of caspase-8, FEES Lett., 493, 26, 2001. 

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