Trafficking desensitization, internalization

Although internalization is also often described to be a phosphorylation-dependent process, Fig. 4c, d shows that receptors do not always require phosphorylation of the same residues to desensitize [137]—and for the recycling of inactivated receptors to the cell membrane [162]—as they do for receptor endocytosis [137, 162], The process of internalization, however, is integral to the membrane trafficking of GPCRs. The mechanisms that are critical to the maintaining the appropriate quantity of receptors at the cell surface [169] can be teased apart using examples from a number of different receptors [170],... 

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