Trafficking cellular localization

P2 is a component of myelin from the peripheral nervous system. It is localized on the cytoplasmic side of Schwann cells where it behaves as peripheral membrane protein, although a small amount is found in the cytoplasm (Trapp et al., 1984). Like the other iLBPs, the exact biochemical role of P2 is unknown. Its cellular localization and its ability to bind different fatty acids and retinoids (Uyemura et al., 1984) suggest that it may function in fatty acid trafficking. It would therefore play a major role in the movement of fatty acids between the site of uptake and that of esterification during the massive phospholipid synthesis phase of myelinating Schwann cells. 

Regulation of the Cellular Localization and Trafficking of the Adrenergic Receptors... 

The family of adrenergic receptors (ARs the ar, a2-, and P-ARs) are key regulators of the sympathetic division of the autonomic nervous system, involved in both central and peripheral cardiovascular function. Here, we review our current understanding of the cellular localization and trafficking properties of the ar, a2-, and P-ARs. We then examine recent evidence indicating that the cellular localization of these receptors and their excursion into intracellular compartments play an underappreciated role in the activation of both G protein and novel non-G protein-dependent cellular signaling. 

Key Words Adrenergic receptors cellular localization or receptors cellular trafficking of receptors receptor subtypes signaling from intracellular receptor complexes. 

In this review, we consider the regulation of cellular localization and trafficking of the family of ARs. Because cellular trafficking appears to be inexorably linked to the activation of novel signaling pathways and the formation of signaling packages within the cell, we also include a discussion of these processes. 

Three arARs (a1A, a1B, and a1D) have been isolated, cloned, and characterized (1,2). Similar to the observations made with the 3-ARs, the cellular localization and trafficking properties of the three oq-ARs do not conform to the dogmatic thinking regarding GPCRs. 

Neufeld EB, Remaley AT, Demosky SJ, et al. (2001) Cellular localization and trafficking of the human ABCAl transporter. J Biol Chem 276 27584-27590... 

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