Tracheal tissue

T. Sugimura, S. Takayama, Biological actions of nitroarenes in short-term tests on Salmonella, cultured mammalian cells and cultured human tracheal tissues Possible basis for regulatory control. Environ. Health Perspect. 47,171-176 (1983)... 

Only shown in rat uterus, not cardiac and tracheal tissue. 

Risbud M., Endres M., Ringe J., Bhonde R., Sittinger M., Biocompatible hydrogel supports the growth of respiratory epi-theUal cells Possibilities in tracheal tissue engineering, 7. Biomed. Mater. Res. Part A, 56,2001, 120-127. 

WaUes, T. Giere, B. Macchiarini, P. Mertsching, H. Expansion of chondrocytes in a three-dimensional matrix for tracheal tissue engineering. Ann. Thoracic Surgery 2004, 78, 444—448. 

Therefore, there is a clear need for a suitable substitute of native tracheal tissue. A successful tracheal replacement would have to be biocompatible and have the rigidity to prevent collapse, but allow flexibility. Once produced, the construct must also be able to vascularize and regenerate ciliated epithelium to become epithehaUzed [79]. Reconstmction of tracheal defects requires the availability of airway epithelial cells, but in addition, it may require the presence of fibroblasts or fibroblast-derived substances [116]. 

PGA scaffolds, wrapped around sUicon hehcal tube, have been implanted in mice and sheep. Tissue morphology and composition resulted to be similar to native tracheal tissue, even if the implanted constructs collapsed and tracheomalacia was observed in sheep after anastomosis. 

S. Taniguchi, Engineering bioartificial tracheal tissue using hybrid fibroblast-mesenchymal stem cell cultures in collagen hydrogels. Interact. Cardiovasc. Thorac. Surg. 12 (2) (Eebruary 2011) 156-161. 

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