Toxophoric groups

There also exist other groups capable of communicating the characteristic toxic functions of the toxophoric group, that is, of... 

Toxophoric Group. —C N —N = C Auxotoxic Group. Halogens, benzyl, etc. 

A drug designer worthy of the name must be conversant with toxification reactions and toxophoric groups (Table 13.15) (6, 21, 227). However, it would be wrong to conclude from... 

In conclusion, the presence of a toxophoric group is not a sufficient condition for observable toxicity, a sobering and often underemphasized fact. Nor is it a necessary condition because other mechanisms of toxicity exist, for example, the acute toxicity characteristic of many solvents. 

Table 32.1 Some major toxophoric groups and their bioactivation mechanisms...

Figure I Toxin c saturates one of the functional groups h of the cell a d is the toxophore group.

Glutaraldehyde (III.2.3) is less reactive than formaldehyde. As a dialdehyde, however, it has two toxophoric groups, which enable it to couple nucleophilic substrates. 

Dialdehydes have two toxophoric groups which are responsible for the antimicrobial effect, i.e. they can react with nucleophilic centres of the microbe cell naturally there is a possibility of manifold connecting reactions. Formaldehyde... 

There are two toxophoric groups in the acrolein molecule, the activated vinyl group and the aldehyde group both groups are able to react with nucleophilic cell entities. Due to this fact acrolein is highly reactive and highly effective and may be defined as a biocide rather than a microbicide. 

However, an exception must be made for those A-hydroxymethyl amides that derive from antimicrobial effective compounds having an amide configuration in the molecule, e.g. a-halogen-amides (introduction of a second toxophoric group into the molecule). 

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