Auxotox groups

Propylpiperonyl) (butyl) diethylene glycol ether (I) (piperonyl butoxide) Modification of auxotoxic group 74 69 98 74... 

In some cases there are actually strongly marked differences. Thus in the coloured substances the auxochrome group brings out the latent colour-potentiality of the chromophore group and so makes colouration possible, while in the war gases the auxotox group merely develops the characteristic property of the toxophor... 

Toxophoric Group. —C N —N = C Auxotoxic Group. Halogens, benzyl, etc. 

Auxotoxic Group. Methyl, ethyl, vinyl, phenyl. Includes Methyl dichloroarsine. . CHgAsCL... 

Experimental work carried out in these laboratories during recent years has been based on the theory that insecticides owe their activity to a toxic nucleus—the toxophore—the properties of which may be modified by auxiliary radicals—the auxotoxes. This nomenclature is suggested by the names of analogous functions in dyestuffs, the chromophore and auxochrome groups. 

A striking illustration of the effect of chemical structure on insecticidal properties is provided by the data given in this paper on compounds related to piperonyl butoxide. According to the above theory, the methylenedioxyphenyl nucleus present in this substance is the toxophore. The materials selected for comparison show the reduction in toxicity produced, first, by modifying the toxophore, and, second, by substituting different groups for the auxotox radical. 

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