Toxicology of FTOHs and FSAs

The 8 2 FTOH, similar to PFOS and PFOA, has also been identified as a peroxisome proliferator [40], and capable of inducing enzymatic activity in the liver and altering hepatic metabolism. In a recent study [41], interaction between the 6 2 and 8 2 FTOHs and human estrogen receptors was also observed, indicating possible estrogenic effects of the FTOHs. 

FSAs such as PFOS A have been observed to inhibit GJIC [38]. In a study by Case, York and Christian [42], NEtFOSE was observed to exhibit development toxicity in mammals and it was generally observed that profiles of developmental toxicity were similar to that of 

PFOS [22]. Unlike PFOS, NEtFOSE has shown no activity as a peroxisome proliferator [43]. It is likely that the toxicological effects of NMeFOSE would be similar to those observed for NEtFOSE. 

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