Toxicity of aromatics

Other Reactants. Other reactants are used in smaller amounts to provide phenoHc resins that have specific properties, especially coatings appHcations. Aniline had been incorporated into both resoles and novolaks but this practice has been generally discontinued because of the toxicity of aromatic amines. Other materials include rosin (abietic acid), dicyclopentadiene, unsaturated oils such as tung oil and linseed oil, and polyvalent cations for cross-linking. 

Except for polybrominated biphenyls (PBB), a limited number of studies regarding the toxicity of aromatic brominated compounds has been performed. Some experiments suggest a moderate acute toxicity of these compounds (ref. 1). 

The physiological effects of the fluoride ion were reviewed by McClure 74) in 1933. Lehmann 72) published an article on the toxicity of aromatic fluorine compounds in 1928. However, it has been impossible to investigate the toxicity of the organofluorine compounds as thoroughly as that of the organochlorine compounds. 

Five different methods are used to establish the relative toxicities of aromatic molecules ... 

Caution. Owing to the toxicity of aromatic hydrocarbons, this procedure should be carried out in a well-ventilated hood. 

Cronin, M.T.D. and Schultz, T.W. 2001. Development of quantitative structure-activity relationships for the toxicity of aromatic compounds to Tetrahymena pyriformis Comparative assessment of the methodologies. Chem. Res. Toxicol. 14 1284-1295. 

Amrolia P, Sullivan SG, Stem A, Munday R (1989) Toxicity of aromatic thiols in the human red blood cell. J Appl Toxicol 9 113-118... 

Aromatic amines are used in the manufacture of rubber chemicals, drugs, dyes, isocyanates, and many other miscellaneous chemical products. The toxicity of aromatic amines has been known and studied for many yearsfH They all penetrate the skin and all produce methemoglobinemia. .) Recently, the Occupational Safety and Health Administration (OSHA) established exposure limits for 14 human carcinogens, several of which are aromatic amines(3)... 

Netzeva TI, Schultz TW. QSARs for the aquatic toxicity of aromatic aldehydes from Tetrahymena data. Chemosphere 2005 61(ll) 1632-43. 

Cronin MTD, Manga N, Seward JR, Sinks GD, Schultz TW. Parametrization of electrophilicity for the prediction of the toxicity of aromatic compounds. Chem Res Toxicol 2001 14(ll) 1498-505. 

Netzeva, T.I., Dearden, J.C., Edwards, R., Worgan, A. D.P. and Cronin, M.T.D. (2004) QSAR analysis on the toxicity of aromatic compounds to Chlordla vulgaris in a novel short-term assay. J. Chan. Inf. Comput. Sci., 44, 258-265. 

D.P. Arfsten, R. Davenport, D.J. Schaeffer (1994). UV-A coexposure enhances the toxicity of aromatic hydrocarbons, munitions, and metals to Photobacterium phos-phoreum. Biomed. Environ. Scl, 7,101-108. 

TABLE 21.2 Chlorine Contents and Toxicity of Aromatic Chloroethers... 

Urrestarazu-Ramos E, Vaal MA, Hermans JLM (2002) Interspecies sensitivity in the aquatic toxicity of aromatic amines. Environ Toxicol Pharmacol 11 149-158... 

Laszlo, T. Beteringhe, A. QSAR studies related to toxicity of aromatic compounds on Tetrahymena pyrifotmis. QSAR Comb. Sci. 2006, 25, 944—951. 

P. R. Dnchowicz, M. G. Vitale, and E. A. Castro, Partial order ranking for the aqueous toxicity of aromatic mixtures, J. Math. Chem. 44 (2008) 541-549. 

SVM Regression QSAR for the Toxicity of Aromatic Compounds to CMorella vulgaris... 

Comput. Sci., 44,258-265 (2004). QSAR Analysis of the Toxicity of Aromatic Compounds to Chlorella vulgaris in a Novel Short-term Assay. 

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