Toxicity evaluation topical application

Insecticidal Activity. Adult houseflies and 3rd instar com earworm larvae were used to evaluate the light induced toxicity of a-T. Rose Bengal was used as the standard. Both species were treated with a series of doses of the test compounds by feeding. In addition, a-T was tested by topical application. Two sets of insects were treated, one of which was kept covered to serve as a dark control. 

Additional considerations for inhalation/intranasal route acute inhalation, application site, and pulmonary sensitization studies for parenteral route acute parenteral toxicity and application site studies mucosal use application site evaluation transdeimal and topical drugs application site and phototoxicity/photoallergy evaluation. Photocarci-nogenicity is a conditional option for transdeimal and topical excipients. 

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