Total iron binding capacity, rats

Serum Total Iron and Total Iron Binding Capacity The results for the determination of serum total iron and total iron-binding capacity of rats fed treatment diets for 18 months are also listed in Table VI. A significant increase in serum total iron was detected in rats fed the Maillard browned egg albumin over their control group. Increased serum total iron with normal total iron binding capacity is associated with hemolytic anemia, hemochromatosis, hemosiderosis, and hepatitis (30 ). On the basis of other clinical and histopathological data, however, none of these causes are likely. 

The effect of administration of benzene on iron metabolism was investigated by giving 0.5 mL/kg intraperitoneally or 1 mL/kg subcutaneously to female rats for 10 consecutive days (Ahmad et al. 1994). Serum from benzene-treated female rats offered less protection against iron-catalyzed lipid peroxidation of brain tissue than the serum of control female rats. Serum iron concentration and total iron binding capacity did not exhibit any significant change after benzene administration. Iron saturation of transferritin was not affected by benzene. 

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