Topliss, John

At the maximum activity of the curve, the derivative equals 0. Solving Equation 12.24 at this point indicates a log P° of —1.20. If additional analogues were to be developed, the discovery team would use this information to include compounds with log P values close to —1.20. John Topliss of the University of Michigan was an early pioneer in QSAR. Topliss felt that the concept of log P° was one of the most important contributions of Hansch analysis to the field of medicinal chemistry.10... 

C. John Blankley inJ. G. Topliss, Ed, Quantitative Structure Activity Relationships of Drugs, Academic Press, New York, 1983,5. 

The series editors wish this book a wide distribution. It is up to the reader to find out which of the properties and descriptors might be most suitable for describing the data. However, the early warnings by Corwin Hansch, John Topliss, and others should not be forgotten make your model as simple as possible test and include only a few parameters try to achieve an understanding of your model use a test set to check the external predictivity of your model. Molecular descriptors are powerful tools in QSAR studies - but their abuse may lead nowhere. May this book further contribute to their selective and proper use ... 

JOHN G. TOPLISS and ROBERT P. EDWARDS Schering-Plough Research Division, Bloomfield, NJ 07003... 

Dow, Strasbourg), Richard Baker (Eli Lilly, Erl Wood, UK), Thomas C. Jones (Sandoz, Basle), Isabelle Morin (Servier, Paris), Bryan Reuben (London South Bank University) and John Topliss (University of Michigan, Ann Arbor) for their invaluable assistance, comments and contributions. 

Chapter 6. Antihypertensive Agents John G. Topliss, Schering Corporation, Bloomfield, N. J. 

EDWARD ENGELHARDT JOHN TOPLISS LLOYD CONOVER IRWIN PACHTER CHARLES SMITH JOSEPH CANNON... 

Section II - Pharmacodynamic Agents Editor John G. Topliss, Schering Corp, Bloomfield, New Jersey... 

EDWARD ENGELHARD JOHN TOPLISS KENNETH BUTLER IRWIN PACHTER WILLIAM WECHTER ROBERT WILEY... 

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