Pharmacodynamic agents

The methodology may also be applicable to the synthesis of pharmacodynamic agents based on the alkoxythiophene core. Such materials should be readily accessible via our new cydization methodology " which utilizes the y-keto acid precursors. 

For pharmacodynamic agents acting within one species (human), selectivity may also be achieved by differences in accumulation, when similar receptors are located in cells or in membranes of different character. The neurotransmitter receptors, for example, are similar, but are found in a variety of highly differentiated cells whose membranes are unlikely to possess the same physical characteristics. 

Section II - Pharmacodynamic Agents Editor John E. Francis, CIBA-GEIGY Corp., Ardsley, N.Y. 

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