Tolerances defined

Steps 2-6 are repeated till the improvement during a certain interval is under the tolerance defined. 

Human pharmacology (Phase I) Assess tolerance Define/describe pharmacokinetics and pharmacodynamics Explore drug metabolism and drug interactions Estimate activity Dose-tolerance studies Single and multiple dose PK and/or PD studies Drug interaction studies... 

Bartholomew and co-workers also measured the loss of catalytic activity with time of Ni and Co bimetallics (157, 194), Ni-molybdenum oxide (23, 113), and borided Ni and Co catalysts (161) during methanation in the presence of 10 ppm H2S. Typical activity versus time plots are shown in Figs. 25 and 26. Activity is defined as the ratio of the mass-based rate of methane production at any time t divided by the initial rate. The activitytime curves are generally characteristic of exponential decay some catalysts decay more slowly than others, but all catalysts suffer at least two orders of magnitude loss in activity within a period of 100-150 hr. Accordingly, it does not appear that other metals or metal oxides in conjunction with Ni significantly change the sulfur tolerance defined in terms of steady-state activity of Ni. These materials can, however, influence the rate at which the... 

The output current tolerance and all other tolerances define an operational range as shown in Fig. 7.9.7. 

Drug tolerance In a retrospective study in 37 patients treated with intrathecal baclofen, the dose increased in the first 18 months after implantation and then stabilized around a mean dose of 350 micrograms/ day [43 ]. Eight patients developed tolerance, defined as a dose increase of over... 

Progression in time or speed as per tolerance—defined as J, Sp02 < 85% or patient fatigue using a dyspnea visual analogue scale. 

The filter (name) is used to refer to a given filter within the reaction block of other requirements, e.g., as shown in Figure 5. The (identifier list) defines how many previous values shall be stored for the filter, the current identifier refers to the current value received by the filter, tolerance defines how many times the filter is allowed to be consecutively triggered before the reaction block is executed and the value expression defines how the masked value is computed by the filter. The reaction block of the filter has the same syntax and semantics as described previously. 

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